SCHEMBL486581

SCHEMBL486581

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nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.54
EYA2 O00167 1/20 0.54
APP P05067 1/20 0.54
ACE P12821 1/20 0.54
TSHR P16473 3/20 0.52
ADRA1A P35348 2/20 0.52
KDM4E B2RXH2 2/20 0.52
BLM P54132 2/20 0.52
PMP22 Q01453 2/20 0.52
LMNA P02545 1/20 0.52
CHRM2 P08172 1/20 0.52
ADRA2A P08913 1/20 0.52
ALOX15 P16050 1/20 0.52
DRD1 P21728 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A4 P31645 1/20 0.52
CYP2C19 P33261 1/20 0.52
DRD3 P35462 1/20 0.52
SLC6A3 Q01959 1/20 0.52
HRH3 Q9Y5N1 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8047064 0.96 TSHR (0.52) TDP1EYA2APPACETSHR
SCHEMBL10002229 0.88 KDM4E (0.45) TDP1EYA2APPACETSHR
Edetic Acid SCHEMBL9299364 0.84 TDP1 (0.52) TDP1EYA2APPACETSHR
SCHEMBL5157765 0.84 KDM4E (0.55) TSHRADRA1AKDM4EBLMMTNR1A
SCHEMBL18307272 0.82 KDM4E (0.48) TSHRADRA1AKDM4EBLMMTNR1A
SCHEMBL16790905 0.81 KDM4E (0.52) TSHRADRA1AKDM4EBLMMTNR1A
SCHEMBL14586734 0.81 BLM (0.49) TDP1EYA2APPACETSHR
SCHEMBL19059678 0.79 ADRA1A (0.47) TDP1EYA2APPACETSHR
SCHEMBL474091 0.77 ALDH1A1 (0.53) TSHRKDM4EBLMPMP22LMNA
SCHEMBL13231974 0.77 TDP1 (0.59) TDP1EYA2APPACETSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2552202-B1 METHODS AND COMPOSITIONS FOR WEIGHT LOSS SDG INC (US) 2023-07-26 EP disclosed
US-11517529-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2022-12-06 US disclosed
EP-3391876-B1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2021-03-10 EP disclosed
US-20200405638-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG INC (US) 2020-12-31 US disclosed
US-10751418-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2020-08-25 US disclosed
US-20200261363-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2020-08-20 US disclosed
US-10568835-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2020-02-25 US disclosed
US-10463616-B2 Lipid construct for delivery of insulin to a mammal SDG, INC. (US) 2019-11-05 US disclosed
US-20190054021-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, INC. 2019-02-21 US disclosed
EP-3391876-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, Inc. (US) 2018-10-24 EP disclosed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 US disclosed
WO-2009042945-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. (AN OHIO CORPORATION ) (US) 2009-04-02 WO disclosed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 US disclosed
EP-1883394-A2 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, Inc. (US) 2008-02-06 EP disclosed
EP-1883395-A2 LIPID CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, Inc. (US) 2008-02-06 EP disclosed
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal SDG, INC. 2007-09-20 US disclosed
WO-2006127361-A2 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, INC. (US) 2006-11-30 WO disclosed
WO-2006127360-A2 LIPID CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. (US) 2006-11-30 WO disclosed
US-20060222698-A1 Hepatocyte delivery vehicle for delivery of glargine insulin to a mammal SDG, INC. 2006-10-05 US disclosed
US-20060222697-A1 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal SDG, INC. 2006-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal HAVCR2, IFNAR1, MSR1 TDP1 4728/4885EYA2 4439/4885APP 2093/4885
US-10568835-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885EYA2 4204/4885APP 747/4885
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC TDP1 4742/4885EYA2 4704/4885APP 531/4885
US-11517529-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885EYA2 4204/4885APP 747/4885
US-20190054021-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL INSR, IAPP, GPR119 TDP1 4882/4885EYA2 3910/4885APP 400/4885
US-20200405638-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, FABP6 TDP1 4819/4885EYA2 4204/4885APP 747/4885
US-20060222698-A1 Hepatocyte delivery vehicle for delivery of glargine insulin to a mammal INSR, GPR119, GCG TDP1 4815/4885EYA2 3580/4885APP 915/4885
US-20090087479-A1 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4757/4885EYA2 4447/4885APP 654/4885
US-20200261363-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL INSR, IAPP, GPR119 TDP1 4882/4885EYA2 3910/4885APP 400/4885
US-10463616-B2 Lipid construct for delivery of insulin to a mammal INSR, IAPP, GPR119 TDP1 4882/4885EYA2 3910/4885APP 400/4885
US-10751418-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885EYA2 4204/4885APP 747/4885
US-20060222697-A1 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal INSR, INSRR, IAPP TDP1 4863/4885EYA2 4188/4885APP 836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.