Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | CD44 | P16070 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11479781 | 0.98 | PNMT (0.58) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL4877761 | 0.92 | ASIC3 (0.60) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL18986604 | 0.82 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL22268691 | 0.79 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL10282808 | 0.77 | PNMT (0.62) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL330080 | 0.75 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL552932 | 0.75 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL420370 | 0.75 | PNMT (0.60) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL329775 | 0.75 | PNMT (1.00) | PNMTADRA2AADRA2BADRA2CDRD2 | |
| SCHEMBL470826 | 0.75 | PNMT (0.66) | PNMTADRA2AADRA2BADRA2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023109909-A1 | AROMATIC HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND USES THEREOF | 上海翊石医药科技有限公司 | 2023-06-22 | — | — | WO | disclosed |
| US-20230002407-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2023-01-05 | — | — | US | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2020210375-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-10-15 | — | — | WO | disclosed |
| US-20190169164-A1 | BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS, INC. | 2019-06-06 | — | — | US | disclosed |
| EP-2703392-B1 | 5-MEMBERED RING AROMATIC HETEROCYCLIC DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO (JP) | 2017-06-14 | — | — | EP | disclosed |
| EP-2703392-A1 | 5-MEMBERED RING AROMATIC HETEROCYCLIC DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY | Shionogi & Co., Ltd. (JP) | 2014-03-05 | — | — | EP | disclosed |
| US-20080096916-A1 | Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants | PFIZER INC. (US) | 2008-04-24 | — | — | US | disclosed |
| EP-1824484-A1 | DRUGS AND PRODRUGS USEFUL FOR THE TREATMENT OF ENERGY BALANCE IN RUMINANTS | Pfizer Products Incorporated (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006054166-A1 | DRUGS AND PRODRUGS USEFUL FOR THE TREATMENT OF ENERGY BALANCE IN RUMINANTS | PFIZER PRODUCTS INC. (US) | 2006-05-26 | — | — | WO | disclosed |
| EP-1633747-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS PPAR-A ACTIVATORS | Pfizer Products Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| US-6987118-B2 | Tetrahydroisoquinoline derivatives as PPAR-alpha activators | PFIZER INC. (US) | 2006-01-17 | — | — | US | disclosed |
| US-20040248934-A1 | Tetrahydroisoquinoline derivatives as PPAR-alpha activators | PFIZER INC. | 2004-12-09 | — | — | US | disclosed |
| WO-2004103997-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS PPAR-α ACTIVATORS | PFIZER PRODUCTS INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| CN-1305470-A | Amidine compounds | JAPAN TOBACCO INC (JP) | 2001-07-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002407-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | PNMT 476/4885ADRA2A 3317/4885ADRA2B 2913/4885 |
| US-20190169164-A1 | BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF | TLR8, TLR3, TLR5 | PNMT 596/4885ADRA2A 796/4885ADRA2B 880/4885 |
| US-20040248934-A1 | Tetrahydroisoquinoline derivatives as PPAR-alpha activators | PPARA, PPARG, PPARD | PNMT 1325/4885ADRA2A 161/4885ADRA2B 304/4885 |
| US-20080096916-A1 | Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants | ALPP, PIGS, GYS2 | PNMT 2457/4885ADRA2A 895/4885ADRA2B 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.