Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878980 | 0.86 | TSHR (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL2494883 | 0.82 | LMNA (0.43) | LMNAMAPTNPSR1ALDH1A1NPC1 | |
| SCHEMBL5281192 | 0.82 | NPC1 (0.47) | LMNAMAPTNPSR1ALDH1A1NPC1 | |
| SCHEMBL10145149 | 0.81 | NPC1 (0.47) | LMNAMAPTNPSR1ALDH1A1NPC1 | |
| SCHEMBL14898280 | 0.80 | LMNA (0.49) | LMNAMAPTNPSR1ALDH1A1NPC1 | |
| SCHEMBL30877124 | 0.80 | MTNR1A (0.39) | NPSR1TSHR | |
| SCHEMBL31679552 | 0.80 | HDAC1 (0.37) | MAPTNPSR1ALDH1A1GAAHPGD | |
| SCHEMBL4876996 | 0.79 | LMNA (0.48) | LMNAMAPTNPSR1ALDH1A1NPC1 | |
| SCHEMBL16141841 | 0.79 | L3MBTL1 (0.38) | NPSR1POLBTSHR | |
| SCHEMBL9135663 | 0.78 | MEP1B (0.41) | LMNAMAPTNPSR1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702426-B2 | Macrocyclic deaza-purinones for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2023-07-18 | — | — | US | disclosed |
| US-11702426-B2 | Macrocyclic deaza-purinones for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2023-07-18 | — | — | US | disclosed |
| US-20210122760-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-04-29 | — | — | US | disclosed |
| US-10829494-B2 | Macrocyclic deaza-purinones for the treatment of viral infections | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-10 | — | — | US | disclosed |
| US-20190330222-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2019-10-31 | — | — | US | disclosed |
| EP-2978429-B1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-02-22 | — | — | EP | disclosed |
| US-20160304531-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC | 2016-10-20 | — | — | US | disclosed |
| US-20160304531-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC | 2016-10-20 | — | — | US | disclosed |
| WO-2014154859-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN R&D IRELAND (IE) | 2014-10-02 | — | — | WO | disclosed |
| US-20080132477-A1 | Macrocyclic Compounds Useful as Bace Inhibitors | NOVARTIS AG (CH) | 2008-06-05 | — | — | US | disclosed |
| EP-1851208-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | Novartis AG (CH) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006074950-A1 | MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210122760-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | DHX15, MAVS, DDX18 | LMNA 1098/4885MAPT 2914/4885NPSR1 3682/4885 |
| US-20160304531-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | DHX15, MAVS, DDX18 | LMNA 1098/4885MAPT 2914/4885NPSR1 3682/4885 |
| US-11702426-B2 | Macrocyclic deaza-purinones for the treatment of viral infections | DHX15, MAVS, DDX18 | LMNA 1098/4885MAPT 2914/4885NPSR1 3682/4885 |
| US-10829494-B2 | Macrocyclic deaza-purinones for the treatment of viral infections | DHX15, MAVS, DDX18 | LMNA 1098/4885MAPT 2914/4885NPSR1 3682/4885 |
| US-20190330222-A1 | MACROCYCLIC DEAZA-PURINONES FOR THE TREATMENT OF VIRAL INFECTIONS | DHX15, MAVS, DDX18 | LMNA 1098/4885MAPT 2914/4885NPSR1 3682/4885 |
| US-20080132477-A1 | Macrocyclic Compounds Useful as Bace Inhibitors | BACE1, BACE2, APP | LMNA 2173/4885MAPT 37/4885NPSR1 1892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.