Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 6/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867749 | 0.89 | ADORA2B (0.33) | ADORA2BADORA1ALOX5CCR5MC4R | |
| SCHEMBL4873106 | 0.83 | ALOX5 (0.33) | ADORA2BALOX5CCR5MEN1KMT2A | |
| SCHEMBL4865612 | 0.82 | CTSV (0.41) | ADORA2BCTSVCTSLCTSBCTSS | |
| SCHEMBL4871994 | 0.80 | ALDH1A1 (0.35) | ADORA2BCTSVCTSLCTSBCTSS | |
| SCHEMBL6621977 | 0.77 | GPR119 (0.41) | MEN1KMT2A | |
| SCHEMBL14256318 | 0.76 | ADORA2B (0.39) | ADORA2BADORA1ALOX5CTSVCTSL | |
| SCHEMBL4874370 | 0.72 | JAK2 (0.46) | — | |
| SCHEMBL6619803 | 0.72 | REN (0.40) | ADORA2BADORA1ALOX5 | |
| SCHEMBL14256332 | 0.72 | REN (0.40) | ADORA2BADORA1ALOX5 | |
| SCHEMBL2845392 | 0.72 | CTSV (0.39) | CTSVCTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |