Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4869554 | 0.99 | ADRA1A (0.55) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL5423788 | 0.98 | HTR1A (0.57) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL5420310 | 0.97 | DRD2 (0.56) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL6110726 | 0.89 | ADRA1A (0.56) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL4527650 | 0.88 | HTR1A (0.56) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL6212337 | 0.88 | DRD2 (0.60) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL6111886 | 0.88 | ADRA1A (0.55) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL6110922 | 0.88 | ADRA1A (0.55) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL6240084 | 0.88 | DRD2 (0.71) | ADRA1AADRA1BADRA1DDRD2DRD3 | |
| SCHEMBL5421922 | 0.88 | ADRA1A (0.49) | ADRA1AADRA1BADRA1DDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167317-A1 | Combination Therapy | RANBAXY LABORATORIES LIMITED (IN) | 2008-07-10 | — | — | US | claimed |
| WO-2006092710-A1 | METABOLITES OF 2-{3-[4-(2-ISOPROPOXYPHENYL) PIPERAZIN-1-YL]-PROPYL}-3A,4,7,7A-TETRAHYDRO-1H-ISOINDOLE-1,3-(2H)-DIONE | RANBAXY LABORATORIES LIMITED (IN) | 2006-09-08 | — | — | WO | claimed |
| WO-2005092342-A1 | COMBINATION THERAPY FOR LOWER URINARY TRACT SYMPTOMS | RANBAXY LABORATORIES LIMITED (IN) | 2005-10-06 | — | — | WO | claimed |
| US-6914064-B2 | 1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoceptor blockers | RANBAXY LABORATORIES LIMITED (IN) | 2005-07-05 | — | — | US | claimed |
| EP-1339682-A1 | 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE $G(A)1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES, LTD. (IN) | 2003-09-03 | — | — | EP | claimed |
| US-20020156085-A1 | 1,4-Disubstituted piperazine derivatives useful as uro-selective alpha1-adrenoceptor blockers | RANBAXY LABORATORIES LIMITED (IN) | 2002-10-24 | — | — | US | claimed |
| WO-2002044151-A1 | 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVE $G(A)1-ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (IN) | 2002-06-06 | — | — | WO | claimed |
| US-20080167317-A1 | Combination Therapy | RANBAXY LABORATORIES LIMITED (IN) | 2008-07-10 | — | — | US | disclosed |
| WO-2006092710-A1 | METABOLITES OF 2-{3-[4-(2-ISOPROPOXYPHENYL) PIPERAZIN-1-YL]-PROPYL}-3A,4,7,7A-TETRAHYDRO-1H-ISOINDOLE-1,3-(2H)-DIONE | RANBAXY LABORATORIES LIMITED (IN) | 2006-09-08 | — | — | WO | disclosed |
| WO-2006092710-A1 | METABOLITES OF 2-{3-[4-(2-ISOPROPOXYPHENYL) PIPERAZIN-1-YL]-PROPYL}-3A,4,7,7A-TETRAHYDRO-1H-ISOINDOLE-1,3-(2H)-DIONE | RANBAXY LABORATORIES LIMITED (IN) | 2006-09-08 | — | — | WO | disclosed |
| WO-2006092710-A1 | METABOLITES OF 2-{3-[4-(2-ISOPROPOXYPHENYL) PIPERAZIN-1-YL]-PROPYL}-3A,4,7,7A-TETRAHYDRO-1H-ISOINDOLE-1,3-(2H)-DIONE | RANBAXY LABORATORIES LIMITED (IN) | 2006-09-08 | — | — | WO | disclosed |
| WO-2005092342-A1 | COMBINATION THERAPY FOR LOWER URINARY TRACT SYMPTOMS | RANBAXY LABORATORIES LIMITED (IN) | 2005-10-06 | — | — | WO | disclosed |
| EP-1495000-A4 | ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE A1A ADRENOCEPTOR BLOCKERS | RANBAXY LAB LTD (IN) | 2005-10-05 | — | — | EP | disclosed |
| US-6914064-B2 | 1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoceptor blockers | RANBAXY LABORATORIES LIMITED (IN) | 2005-07-05 | — | — | US | disclosed |
| EP-1495000-A1 | ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE A1A ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES, LTD. (IN) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003084928-A1 | ALPHA, OMEGA-DICARBOXIMIDE DERIVATIVES AS USEFUL URO-SELECTIVE Α1Α ADRENOCEPTOR BLOCKERS | RANBAXY LABORATORIES LIMITED (IN) | 2003-10-16 | — | — | WO | disclosed |
| US-20020156085-A1 | 1,4-Disubstituted piperazine derivatives useful as uro-selective alpha1-adrenoceptor blockers | RANBAXY LABORATORIES LIMITED (IN) | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156085-A1 | 1,4-Disubstituted piperazine derivatives useful as uro-selective alpha1-adrenoceptor blockers | ADRB1, ADRB2, ADRA1B | ADRA1A 4/4885ADRA1B 3/4885ADRA1D 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.