Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.42 |
| ▸ | RXRG | P48443 | 3/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874857 | 0.91 | RXRA (0.46) | RXRARXRBRXRGMCL1FOLH1 | |
| SCHEMBL4437175 | 0.71 | RXRA (0.52) | RXRARXRBRXRGGLRA1MCL1 | |
| SCHEMBL21327456 | 0.70 | LRRK2 (0.57) | GLRA1MCL1FOLH1SMPD1HDAC1 | |
| SCHEMBL9201143 | 0.69 | FOLH1 (0.52) | RXRARXRBRXRGMCL1FOLH1 | |
| SCHEMBL341109 | 0.68 | SGMS2 (0.62) | FOLH1MAPTL3MBTL1PTGER1 | |
| SCHEMBL9336507 | 0.68 | MAPT (0.63) | RXRARXRBRXRGGLRA1MCL1 | |
| SCHEMBL13932500 | 0.68 | GLRA1 (0.65) | GLRA1HPGD | |
| SCHEMBL4468346 | 0.68 | GLRA1 (0.57) | GLRA1MCL1FOLH1MAPTCYP2C9 | |
| SCHEMBL21327204 | 0.67 | MCL1 (0.54) | RXRARXRBRXRGGLRA1MCL1 | |
| SCHEMBL13819477 | 0.67 | MCL1 (0.54) | GLRA1MCL1FOLH1MAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070850-A1 | GALLOTANNINS AND ELLIGITANNINS AS REGULATORS OF CYTOKINE RELEASE | THE PENN STATE RESEARCH FOUNDATION (US) | 2008-03-20 | — | — | US | disclosed |
| US-7288273-B1 | Gallotannins and ellagitannins as regulators of cytokine release | THE PENN STATE RESEARCH FOUNDATION (US) | 2007-10-30 | — | — | US | disclosed |
| EP-1232169-A1 | GALLOTANNINS AND ELLAGITANNINS AS REGULATORS OF CYTOKINE RELEASE | THE PENN STATE RESEARCH FOUNDATION (US) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001036436-A1 | GALLOTANNINS AND ELLAGITANNINS AS REGULATORS OF CYTOKINE RELEASE | THE PENN STATE RESEARCH FOUNDATION (US) | 2001-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070850-A1 | GALLOTANNINS AND ELLIGITANNINS AS REGULATORS OF CYTOKINE RELEASE | IL2, IL6, TNF | RXRA 4456/4885RXRB 4276/4885RXRG 4155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.