Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712666 | 0.81 | NOTUM (0.42) | MEN1KMT2APOLBALDH1A1MMP2 | |
| SCHEMBL10545631 | 0.77 | PKM (0.49) | MAPTKMT2APKMHTTALDH1A1 | |
| SCHEMBL1976805 | 0.75 | CA1 (0.50) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL5694221 | 0.74 | RAPGEF4 (0.45) | MAPTKMT2ACA1CA2HTT | |
| SCHEMBL14273105 | 0.73 | CA1 (0.62) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL5694032 | 0.72 | GAA (0.42) | PKMHTTALDH1A1L3MBTL1GAA | |
| SCHEMBL1826706 | 0.71 | CA1 (0.46) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL4993025 | 0.69 | GRM4 (0.51) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL28229562 | 0.68 | PTGS2 (0.57) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL11068977 | 0.68 | SLC9A1 (0.50) | MAPTMEN1KMT2ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115298192-A | 4' -O-methylene phosphonate nucleic acids and analogs thereof | 迪克纳制药公司 | 2022-11-04 | — | — | CN | disclosed |
| US-20080119419-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2008-05-22 | — | — | US | disclosed |
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-20060264385-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2006-11-23 | — | — | US | disclosed |
| US-7091196-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050197334-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2005-09-08 | — | — | US | disclosed |
| EP-1543017-A2 | BIFUNCTIONAL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | Rib-X Pharmaceuticals, Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004029066-A2 | BIFUNCTIONAL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119419-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | MAPT 4553/4885MEN1 448/4885KMT2A 4043/4885 |
| US-20060264385-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | MAPT 4553/4885MEN1 448/4885KMT2A 4043/4885 |
| US-20050197334-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | MAPT 4553/4885MEN1 448/4885KMT2A 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.