SCHEMBL1826706

SCHEMBL1826706

Cc1ccc(S(=O)(=O)n2cncn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
PKM P14618 3/20 0.44
POLB P06746 2/20 0.43
HTT P42858 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MMP2 P08253 1/20 0.43
ALDH3A1 P30838 2/20 0.43
NOD1 Q9Y239 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MAPT P10636 2/20 0.42
LMNA P02545 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
GAA P10253 3/20 0.42
CXCL8 P10145 1/20 0.41
NOD2 Q9HC29 1/20 0.41
ACHE P22303 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11073965 0.81 CYP19A1 (0.43) MEN1KMT2APOLBALDH1A1MMP2
SCHEMBL24670440 0.78 CA1 (0.44) CA1CA2MEN1KMT2AALDH1A1
SCHEMBL1096992 0.78 PARL (0.47) CA1CA2MEN1KMT2APKM
SCHEMBL24668714 0.78 TP53 (0.38) KMT2APKMSMN1; SMN2
SCHEMBL2386706 0.74 RAPGEF4 (0.45) CA1CA2MEN1KMT2AHTT
SCHEMBL4993025 0.73 GRM4 (0.51) CA1CA2MEN1KMT2APKM
SCHEMBL29509 0.72 ALDH1A1 (0.45) CA1CA2KMT2APKMPOLB
SCHEMBL4881482 0.71 MAPT (0.47) CA1CA2MEN1KMT2APKM
SCHEMBL3316587 0.71 CA1 (0.55) CA1CA2MEN1KMT2APKM
SCHEMBL24254271 0.71 KMT2A (0.49) MEN1KMT2APKMPOLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114805229-B Preparation of 1,2, 4-triazole 兰州大学 2023-04-25 CN claimed
CN-114805229-A Preparation of 1,2, 4-triazoles 兰州大学 2022-07-29 CN claimed
WO-2008034644-A2 PROCESS FOR MAKING ANASTROZOLE SYNTHON B.V. (NL) 2008-03-27 WO claimed
US-20080076933-A1 PROCESS FOR MAKING ANASTROZOLE SYNTHON BV (NL) 2008-03-27 US claimed
CN-113923988-B Substituted arylmethyl ureas and heteroarylmethyl ureas, analogs thereof, and methods of using the same 爱彼特生物制药公司 2024-12-13 CN disclosed
EP-3893645-B1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (CA) 2024-04-17 EP disclosed
CN-114805229-B Preparation of 1,2, 4-triazole 兰州大学 2023-04-25 CN disclosed
CN-114805229-B Preparation of 1,2, 4-triazole 兰州大学 2023-04-25 CN disclosed
US-20230045421-A1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (CA) 2023-02-09 US disclosed
US-20230045421-A1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (CA) 2023-02-09 US disclosed
CN-114805229-A Preparation of 1,2, 4-triazoles 兰州大学 2022-07-29 CN disclosed
CN-114805229-A Preparation of 1,2, 4-triazoles 兰州大学 2022-07-29 CN disclosed
WO-2008034644-A2 PROCESS FOR MAKING ANASTROZOLE SYNTHON B.V. (NL) 2008-03-27 WO disclosed
WO-2008034644-A2 PROCESS FOR MAKING ANASTROZOLE SYNTHON B.V. (NL) 2008-03-27 WO disclosed
US-20060155136-A1 Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same KANEKA CORPORATION (JP) 2006-07-13 US disclosed
EP-1647551-A1 OPTICALLY ACTIVE HALOHYDRIN DERIVATIVE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE EPOXY ALCOHOL DERIVATIVE FROM THE SAME KANEKA CORPORATION (JP) 2006-04-19 EP disclosed
EP-0613890-A1 Novel triazole compound, process for preparing the same and antifungal agent containing the same NIHON NOHYAKU CO., LTD. (JP) 1994-09-07 EP disclosed
EP-0009998-B1 PEROXYGEN CONTAINING COMPOSITIONS AND BLEACHING PROCESS FMC Corporation (US) 1984-03-14 EP disclosed
US-4230591-A Peroxygen bleaching and compositions therefor FMC CORPORATION (US) 1980-10-28 US disclosed
US-4207070-A Peroxygen bleaching and compositions therefor FMC CORPORATION (US) 1980-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060155136-A1 Optically active halohydrin derivative and process for producing optically active epoxy alcohol derivative from the same TALDO1, CYP51A1, ERG28 CA1 1130/4885CA2 752/4885MEN1 3817/4885
US-20080076933-A1 PROCESS FOR MAKING ANASTROZOLE CYP19A1, CYP3A4, CYP2C19 CA1 3496/4885CA2 4294/4885MEN1 1523/4885
US-20230045421-A1 SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME HAVCR2, HMBS, AHCY CA1 4853/4885CA2 4816/4885MEN1 1955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.