Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | LSS | P48449 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.54 |
| ▸ | KDM1A | O60341 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 2/20 | 0.52 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.51 |
| ▸ | STAMBP | O95630 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882259 | 0.86 | MLYCD (0.59) | MAPK14ROCK2ROCK1MLYCD | |
| SCHEMBL4879066 | 0.84 | ROCK2 (0.68) | MAPK14HDAC1NAMPTROCK2ROCK1 | |
| SCHEMBL18741074 | 0.84 | L3MBTL1 (0.61) | MAPK14EPHX2PPARGSTAMBPROCK2 | |
| SCHEMBL4879445 | 0.81 | ROCK2 (0.60) | ROCK2ROCK1L3MBTL1HDAC2HDAC6 | |
| SCHEMBL1568311 | 0.81 | L3MBTL1 (0.74) | MAPK14LSSHDAC1KDM1AEPHX2 | |
| SCHEMBL18741154 | 0.81 | ROCK2 (0.54) | ROCK2ROCK1 | |
| SCHEMBL2634030 | 0.79 | MAPK14 (0.76) | MAPK14LSSHDAC1EPHX2PPARG | |
| SCHEMBL31023451 | 0.79 | EPHX2 (0.62) | HDAC1EPHX2ROCK2ROCK1HDAC3 | |
| SCHEMBL15873800 | 0.78 | L3MBTL1 (0.58) | HDAC1EPHX2NAMPTROCK2ROCK1 | |
| SCHEMBL4497840 | 0.78 | LSS (0.69) | MAPK14LSSHDAC1KDM1AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | ICAGEN, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-7223782-B2 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | ICAGEN, INC. (US) | 2005-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064690-A1 | PYRAZOLE-AMIDES AND -SULFONAMIDES | SCN3A, TRPV3, HCN3 | MAPK14 1270/4885LSS 1948/4885HDAC1 949/4885 |
| US-20050049237-A1 | Pyrazole-amides and -sulfonamides | SCN3A, TRPV3, HCN3 | MAPK14 1270/4885LSS 1948/4885HDAC1 949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.