Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 2/20 | 0.32 |
| ▸ | IDH1 | O75874 | 2/20 | 0.31 |
| ▸ | PER2 | O15055 | 1/20 | 0.31 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 3/20 | 0.31 |
| ▸ | MAOA | P21397 | 3/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30980973 | 0.80 | PIK3CD (0.39) | EGLN2ALOX5BACE1TNKSNAAA | |
| SCHEMBL3587464 | 0.77 | PSEN1 (0.38) | EGLN2ELOVL6MTORCMA1CCR6 | |
| SCHEMBL30669251 | 0.74 | FADS1 (0.50) | ALOX5BACE1NAAAKDM1AMAOA | |
| SCHEMBL3927618 | 0.73 | EGLN2 (0.36) | EGLN2TNKSELOVL6PIK3CAMTOR | |
| SCHEMBL6099462 | 0.73 | TNKS (0.45) | TNKSELOVL6NAAAKDM1AMAOA | |
| SCHEMBL26298453 | 0.72 | EGLN2 (0.40) | EGLN2TNKSMAP2K1PIK3CAMTOR | |
| SCHEMBL30980936 | 0.72 | DRD2 (0.40) | IDH1PER2CRY2CMA1 | |
| SCHEMBL11595049 | 0.71 | IDH1 (0.40) | EGLN2TNKSMAP2K1IDH1CMA1 | |
| SCHEMBL5486378 | 0.71 | PRKAG1 (0.40) | EGLN2TNKSMAP2K1NAAAIDH1 | |
| SCHEMBL13167926 | 0.69 | HSP90AA1 (0.39) | EGLN2TNKSPIK3CAMTORIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119419-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2008-05-22 | — | — | US | disclosed |
| US-7335753-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-20060264385-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2006-11-23 | — | — | US | disclosed |
| US-7091196-B2 | Bifunctional heterocyclic compounds and methods of making and using same | RIB-X PHARMACEUTICALS, INC. (US) | 2006-08-15 | — | — | US | disclosed |
| US-20050197334-A1 | Bifunctional heterocyclic compounds and methods of making and using same | BioVersys AG (CH) | 2005-09-08 | — | — | US | disclosed |
| EP-1543017-A2 | BIFUNCTIONAL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | Rib-X Pharmaceuticals, Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004029066-A2 | BIFUNCTIONAL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2004-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119419-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | EGLN2 2273/4885ALOX5 392/4885BACE1 4140/4885 |
| US-20060264385-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | EGLN2 2273/4885ALOX5 392/4885BACE1 4140/4885 |
| US-20050197334-A1 | Bifunctional heterocyclic compounds and methods of making and using same | PCNA, DCX, ATIC | EGLN2 2273/4885ALOX5 392/4885BACE1 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.