SCHEMBL4886950

SCHEMBL4886950

CC(C)(C)OC(=O)N[C@H](C(=O)N1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1)C(C)(C)C

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 1/20 0.48
HTR1A P08908 11/20 0.44
HTR7 P34969 11/20 0.44
EPHX2 P34913 1/20 0.44
NR1H2 P55055 1/20 0.43
NR1H3 Q13133 1/20 0.43
DRD2 P14416 3/20 0.42
HTR6 P50406 2/20 0.42
RORC P51449 1/20 0.42
DPP4 P27487 1/20 0.42
KCNH2 Q12809 1/20 0.42
DPP7 Q9UHL4 1/20 0.42
POLB P06746 1/20 0.42
HTR2A P28223 1/20 0.42
ADRA1D P25100 1/20 0.42
ADRA1A P35348 1/20 0.42
ADRA1B P35368 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4883056 0.83 KMT2A (0.52) HTR1AHTR7POLB
SCHEMBL4885026 0.82 MMP13 (0.42) MMP13HTR1AHTR7EPHX2DRD2
SCHEMBL4602370 0.82 MMP13 (0.63) MMP13HTR1AHTR7NR1H2NR1H3
SCHEMBL4888091 0.80 EPHX2 (0.55) EPHX2
Hydrochloric Acid SCHEMBL4881423 0.79 DPP4 (0.49) HTR1AHTR7EPHX2RORCDPP4
Hydrochloric Acid SCHEMBL4881432 0.79 DPP4 (0.49) HTR1AHTR7EPHX2RORCDPP4
SCHEMBL4885197 0.78 MMP2 (0.44) HTR1AHTR7EPHX2
SCHEMBL4883757 0.77 MMP3 (0.48)
SCHEMBL6538880 0.75 MEN1 (0.66) HTR1AHTR7EPHX2DRD2HTR6
SCHEMBL13873237 0.74 EPHX2 (0.56) HTR1AHTR7EPHX2DRD2HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof PDF, PEPD, DHPS MMP13 740/4885HTR1A 3793/4885HTR7 3840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.