SCHEMBL4888152

SCHEMBL4888152

NCCCCC(NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)Nc1ccc(CC2(C(N)=O)CCCCC2)cc1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MME P08473 1/20 0.49
▸ ACE P12821 1/20 0.49
▸ ECE1 P42892 1/20 0.49
▸ UTS2R Q9UKP6 1/20 0.47
▸ GHSR Q92847 2/20 0.47
▸ RUVBL1 Q9Y265 4/20 0.46
▸ BDKRB2 P30411 1/20 0.44
▸ NPY1R P25929 1/20 0.44
▸ NPY2R P49146 1/20 0.44
▸ NPY4R P50391 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4888158 0.84 BDKRB2 (0.51) UTS2RGHSRRUVBL1BDKRB2
SCHEMBL4888144 0.83 UTS2R (0.47) UTS2RGHSRRUVBL1BDKRB2
Hydrochloric Acid SCHEMBL6290405 0.82 RUVBL1 (0.54) UTS2RGHSRRUVBL1
Hydrochloric Acid SCHEMBL6287792 0.82 RUVBL1 (0.54) UTS2RGHSRRUVBL1
SCHEMBL14111057 0.79 GHSR (0.46) GHSR
SCHEMBL4885605 0.79 KDM1A (0.47) NPY1R
SCHEMBL4886967 0.78 CHRNB2 (0.47) BDKRB2
SCHEMBL4887077 0.78 PLG (0.45) —
SCHEMBL4884651 0.78 NTMT1 (0.46) —
SCHEMBL29603261 0.77 KDM4E (0.59) ACEUTS2RGHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080171783-A1 COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE MIGENIX INC. (CA) 2008-07-17 — — US disclosed
US-20070021434-A1 NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF MIGENIX INC. (CA) 2007-01-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021434-A1 NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF HAVCR2, ADAR, NSUN2 MME 484/4885ACE 282/4885ECE1 1442/4885
US-20080171783-A1 COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE POLQ, POLI, POLH MME 1824/4885ACE 891/4885ECE1 1952/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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