Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655130 | 0.88 | RAD52 (0.50) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL9063730 | 0.87 | GRIN1 (0.51) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL485969 | 0.84 | GRIN1 (0.43) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL7653718 | 0.84 | TDP1 (0.47) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL3391736 | 0.84 | GRIN1 (0.43) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL7765425 | 0.84 | DDAH1 (0.53) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL11327259 | 0.80 | GRIN1 (0.41) | GRIN1GRIN2BIMPDH2IMPDH1PIN1 | |
| SCHEMBL5795358 | 0.79 | GRIN1 (0.64) | GRIN1GRIN2BMAPK10CYP19A1 | |
| SCHEMBL4069583 | 0.79 | PIN1 (0.49) | GRIN1GRIN2BPIN1MAPK10CYP19A1 | |
| SCHEMBL11249156 | 0.78 | MASP2 (0.48) | IMPDH2IMPDH1PIN1MAPK10PKN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045537-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-02-21 | — | — | US | disclosed |
| CN-101039672-A | Chemical compounds | SMITHKLINE BEECHAM CORP (US) | 2007-09-19 | — | — | CN | disclosed |
| EP-1789045-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006023400-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045537-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | CACNA1H 4406/4885GRIN1 1866/4885GRIN2B 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.