Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.43 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893300 | 1.00 | HSD17B10 (0.47) | HSD17B10LMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL3266005 | 0.80 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1GLATSHRIRAK4 | |
| SCHEMBL3266008 | 0.80 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1GLATSHRIRAK4 | |
| SCHEMBL14347222 | 0.80 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1GLATSHRIRAK4 | |
| SCHEMBL10377143 | 0.76 | POLB (0.63) | HSD17B10LMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL7529202 | 0.75 | NR4A2 (0.59) | HSD17B10LMNASMN1; SMN2ALDH1A1GLA | |
| SCHEMBL29847389 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GLAHPGDTSHR | |
| SCHEMBL2338368 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GLAHPGDTSHR | |
| SCHEMBL7962011 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GLAHPGDTSHR | |
| SCHEMBL7962015 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GLAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130331395-A1 | BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-12 | — | — | US | disclosed |
| US-8530475-B2 | Serotonin reuptake inhibitors and antagonists of the serotonin 1A receptor; compounds are based on 7,9-diazabicyclo(4.2.2)dec-3-ene ring | JANSSEN PHARMACEUTICA NV | 2013-09-10 | — | — | US | disclosed |
| US-20080070919-A1 | BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS | CREIGHTON CHRISTOPHER J | 2008-03-20 | — | — | US | disclosed |
| WO-2007137168-A2 | BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070919-A1 | BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS | HTR1A, HTR5A, TPH1 | HSD17B10 1019/4885LMNA 2932/4885SMN1; SMN2 1837/4885 |
| US-20130331395-A1 | BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS | HTR1A, HTR5A, TPH1 | HSD17B10 1019/4885LMNA 2932/4885SMN1; SMN2 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.