Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 3/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3543531 | 0.80 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1KMT2AMAPTMGLL | |
| SCHEMBL10013747 | 0.77 | HTT (0.72) | SMN1; SMN2PKMALDH1A1MAPTHTT | |
| SCHEMBL4893392 | 0.77 | LMNA (0.62) | SMN1; SMN2ALDH1A1KMT2AHTTAKR1C3 | |
| SCHEMBL2763863 | 0.77 | BCHE (0.45) | SMN1; SMN2ALDH1A1KMT2AMGLLFAAH | |
| SCHEMBL13161999 | 0.77 | ALDH1A1 (0.60) | SMN1; SMN2PKMALDH1A1KMT2AMAPT | |
| SCHEMBL28607452 | 0.75 | PKM (0.57) | SMN1; SMN2PKMALDH1A1KMT2AMAPT | |
| SCHEMBL12123820 | 0.74 | KMT2A (0.64) | ALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL28291405 | 0.74 | SMN1; SMN2 (0.57) | SMN1; SMN2PKMALDH1A1MAPTHTT | |
| SCHEMBL8735550 | 0.73 | ERCC5 (0.74) | SMN1; SMN2KMT2AERCC5FEN1NPC1 | |
| SCHEMBL18397667 | 0.70 | SMN1; SMN2 (0.52) | SMN1; SMN2PKMALDH1A1HTTMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293721-A1 | ARYLTHIOACETAMIDE CARBOXYLATE DERIVATIVES AS FKBP INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISEASES | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293721-A1 | ARYLTHIOACETAMIDE CARBOXYLATE DERIVATIVES AS FKBP INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISEASES | FKBP3, FKBP2, FKBP1B | SMN1; SMN2 228/4885PKM 1269/4885ALDH1A1 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.