Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | WNT3 | P56703 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4894257 | 0.94 | GPR119 (0.52) | SFRP1GPR119 | |
| SCHEMBL4891019 | 0.91 | SFRP1 (0.49) | SFRP1GPR119WNT3 | |
| SCHEMBL27703338 | 0.86 | LMNA (0.42) | SFRP1 | |
| SCHEMBL4899075 | 0.86 | GPR119 (0.51) | GPR119 | |
| SCHEMBL4889857 | 0.85 | GPR119 (0.49) | SFRP1GPR119 | |
| SCHEMBL4902144 | 0.84 | TGFBR1 (0.49) | GPR119 | |
| SCHEMBL4901336 | 0.84 | GPR119 (0.48) | GPR119 | |
| SCHEMBL4894091 | 0.83 | GPR119 (0.49) | GPR119 | |
| SCHEMBL4898822 | 0.83 | GPR119 (0.51) | GPR119 | |
| SCHEMBL3940077 | 0.83 | USP30 (0.49) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318933-A1 | 5-Sulfonyl-1-Piperidinyl Substituted Indole Derivatives as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders | GLAXO GROUP LIMITED | 2008-12-25 | — | — | US | disclosed |
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318933-A1 | 5-Sulfonyl-1-Piperidinyl Substituted Indole Derivatives as 5-Ht6 Receptor Antagonists for the Treatment of Cns Disorders | HTR6, HTR5A, TPH1 | SFRP1 1090/4885GPR119 33/4885USP30 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.