Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4894083 | 0.98 | NAPRT (0.60) | NAPRTGSK3BGRM4RAB9ANPC1 | |
| SCHEMBL1985578 | 0.86 | NAPRT (0.64) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6439911 | 0.84 | NAPRT (0.62) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6389786 | 0.82 | NAPRT (0.60) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL30093343 | 0.82 | NAPRT (0.60) | NAPRTGSK3BGRM4RAB9ANPC1 | |
| SCHEMBL30175321 | 0.82 | NAPRT (0.60) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL196686 | 0.82 | NAPRT (0.60) | NAPRTGSK3BGRM4RAB9ANPC1 | |
| SCHEMBL1877325 | 0.82 | NAPRT (0.60) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3299695 | 0.82 | NAPRT (0.55) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL12098974 | 0.81 | NAPRT (0.58) | NAPRTGRM4RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255364-A1 | Method For The Production A-Chloroalkylpyridyl Ketones And/Or The Hydrochlorides Thereof | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-16 | — | — | US | claimed |
| EP-1751110-A1 | METHOD FOR THE PRODUCTION OF A-CHLOROALKYLPYRIDYL KETONES AND/OR THE HYDROCHLORIDES THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113505-A1 | METHOD FOR THE PRODUCTION OF A-CHLOROALKYLPYRIDYL KETONES AND/OR THE HYDROCHLORIDES THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2005-12-01 | — | — | WO | claimed |
| US-20250051316-A1 | 2-(ARYL-2-YL) MORPHOLINE AND DEUTERATED DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) | 2025-02-13 | — | — | US | disclosed |
| EP-4428128-A1 | 2-(ARYL-2-YL) MORPHOLINE AND DEUTERATED DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023078392-A1 | 2-(ARYL-2-YL) MORPHOLINE AND DEUTERATED DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-05-11 | — | — | WO | disclosed |
| WO-2023078392-A1 | 2-(ARYL-2-YL) MORPHOLINE AND DEUTERATED DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-05-11 | — | — | WO | disclosed |
| EP-3116858-B1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC (JP) | 2020-11-11 | — | — | EP | disclosed |
| US-20180339993-A1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2018-11-29 | — | — | US | disclosed |
| US-10093678-B2 | Azaspiro derivatives as TRPM8 antagonists | RAQUALIA PHARMA INC. (JP) | 2018-10-09 | — | — | US | disclosed |
| EP-2688870-B1 | HETEROCYCLIC AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-02-01 | — | — | EP | disclosed |
| WO-2012123298-A1 | ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-09-20 | — | — | WO | disclosed |
| US-20120230951-A1 | ANTIVIRAL COMPOUNDS | ALAM MUZAFFAR (US) | 2012-09-13 | — | — | US | disclosed |
| US-20080255364-A1 | Method For The Production A-Chloroalkylpyridyl Ketones And/Or The Hydrochlorides Thereof | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-16 | — | — | US | disclosed |
| US-20080255364-A1 | Method For The Production A-Chloroalkylpyridyl Ketones And/Or The Hydrochlorides Thereof | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-16 | — | — | US | disclosed |
| US-20080255364-A1 | Method For The Production A-Chloroalkylpyridyl Ketones And/Or The Hydrochlorides Thereof | BASF AKTIENGESELLSCHAFT (DE) | 2008-10-16 | — | — | US | disclosed |
| EP-1751110-A1 | METHOD FOR THE PRODUCTION OF A-CHLOROALKYLPYRIDYL KETONES AND/OR THE HYDROCHLORIDES THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005113505-A1 | METHOD FOR THE PRODUCTION OF A-CHLOROALKYLPYRIDYL KETONES AND/OR THE HYDROCHLORIDES THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2005-12-01 | — | — | WO | disclosed |
| EP-0506729-A1 | PHARMACEUTICALLY ACTIVE OXAZOLE COMPOUNDS | Beecham Group p.l.c. (GB) | 1992-10-07 | — | — | EP | disclosed |
| WO-1991009856-A1 | PHARMACEUTICALLY ACTIVE OXAZOLE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1991-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250051316-A1 | 2-(ARYL-2-YL) MORPHOLINE AND DEUTERATED DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | TAAR1, TAAR5, AVPR2 | NAPRT 1520/4885GSK3B 1561/4885GRM4 752/4885 |
| US-10093678-B2 | Azaspiro derivatives as TRPM8 antagonists | TRPM8, TRPM7, TRPM5 | NAPRT 271/4885GSK3B 2725/4885GRM4 889/4885 |
| US-20180339993-A1 | AZASPIRO DERIVATIVES AS TRPM8 ANTAGONISTS | TRPM8, TRPM7, TRPM6 | NAPRT 285/4885GSK3B 2584/4885GRM4 870/4885 |
| US-20120230951-A1 | ANTIVIRAL COMPOUNDS | HAVCR2, EIF2AK2, MAVS | NAPRT 2242/4885GSK3B 575/4885GRM4 3914/4885 |
| US-20080255364-A1 | Method For The Production A-Chloroalkylpyridyl Ketones And/Or The Hydrochlorides Thereof | CBS, PCCA, ALK | NAPRT 3586/4885GSK3B 3329/4885GRM4 4562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.