Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520770 | 0.88 | RAB9A (0.78) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL1520968 | 0.88 | SMN1; SMN2 (0.57) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL18499086 | 0.84 | RAB9A (0.50) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL13752162 | 0.83 | RAB9A (0.70) | RAB9ASMN1; SMN2NPC1MAPTTSHR | |
| SCHEMBL13067250 | 0.83 | ALDH1A1 (0.47) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL10847008 | 0.83 | SMN1; SMN2 (0.53) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL27344768 | 0.83 | SMN1; SMN2 (0.53) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL14645653 | 0.81 | HTT (0.65) | RAB9ASMN1; SMN2NPC1MAPTPKM | |
| SCHEMBL12766911 | 0.81 | TOP2A (0.57) | SMN1; SMN2MAPTALDH1A1KMT2ATDP1 | |
| SCHEMBL16920970 | 0.81 | RAB9A (0.68) | RAB9ASMN1; SMN2NPC1MAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |
| JP-5059015-A | — | — | None | — | — | JP | disclosed |
| US-9510593-B2 | S-benzylthiouracil compounds and methods of enhancing plant root growth | VALENT BIOSCIENCES CORPORATION (US) | 2016-12-06 | — | — | US | disclosed |
| US-9510593-B2 | S-benzylthiouracil compounds and methods of enhancing plant root growth | VALENT BIOSCIENCES CORPORATION (US) | 2016-12-06 | — | — | US | disclosed |
| US-20150201620-A1 | S-BENZYLTHIOURACIL COMPOUNDS AND METHODS OF ENHANCING PLANT ROOT GROWTH | VALENT BIOSCIENCES LLC | 2015-07-23 | — | — | US | disclosed |
| US-20150201620-A1 | S-BENZYLTHIOURACIL COMPOUNDS AND METHODS OF ENHANCING PLANT ROOT GROWTH | VALENT BIOSCIENCES LLC | 2015-07-23 | — | — | US | disclosed |
| WO-2015108938-A1 | S-BENZYLTHIOURACIL COMPOUNDS AND METHODS OF ENHANCING PLANT ROOT GROWTH | VALENT BIOSCIENCES CORPORATION (US) | 2015-07-23 | — | — | WO | disclosed |
| US-20130289083-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-20130289083-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| EP-1527051-B1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| US-20050234077-A1 | Pyrimidine compounds and their use as modulators of chemokine receptor activity | ASTRAZENECA AB, A SWEDEN CORPORATION | 2005-10-20 | — | — | US | disclosed |
| EP-1527051-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | Astrazeneca AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004011443-A1 | PYRIMIDYL SULPHONE AMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |
| US-20030040523-A1 | Pyrimidine compounds and their use as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2003-02-27 | — | — | US | disclosed |
| EP-1265899-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001058902-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | disclosed |
| CN-1046270-C | Pyrimidine-thloalkyl and alkylether compounds | PHARMACIA UPJOHN COMPANY (US) | 1999-11-10 | — | — | CN | disclosed |
| CN-1134697-A | Pyrimidine-sulfanyl and alkyl ether compounds | UPJOHN CO (US) | 1996-10-30 | — | — | CN | disclosed |
| JP-H0559015-A | PYRIMIDINE DERIVATIVE AND HERBICIDE CONTAINING THE SAME DERIVATIVE AS ACTIVE INGREDIENT | OTSUKA CHEM CO LTD | 1993-03-09 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150201620-A1 | S-BENZYLTHIOURACIL COMPOUNDS AND METHODS OF ENHANCING PLANT ROOT GROWTH | SRM, TST, BROX | RAB9A 2155/4885SMN1; SMN2 4861/4885NPC1 3739/4885 |
| US-20030040523-A1 | Pyrimidine compounds and their use as modulators of chemokine receptor activity | CCR5, CXCR1, CXCR4 | RAB9A 2666/4885SMN1; SMN2 4674/4885NPC1 1708/4885 |
| US-20050234077-A1 | Pyrimidine compounds and their use as modulators of chemokine receptor activity | CXCR4, CXCR1, CXCR2 | RAB9A 2676/4885SMN1; SMN2 4685/4885NPC1 1898/4885 |
| US-20130289083-A1 | IDO Inhibitors | IDO1, IDO2, INMT | RAB9A 4202/4885SMN1; SMN2 4556/4885NPC1 3727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.