SCHEMBL490325

SCHEMBL490325

[c]1ccc2c3c(cccc13)-c1ccccc1-2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 5/20 0.44
ALDH1A1 P00352 3/20 0.44
TSHR P16473 3/20 0.44
HSD17B10 Q99714 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
ATM Q13315 2/20 0.44
CASP1 P29466 3/20 0.35
CASP7 P55210 2/20 0.35
PABPC1 P11940 2/20 0.35
CYP3A4 P08684 1/20 0.35
DNMT1 P26358 1/20 0.35
CRHBP P24387 1/20 0.35
CRHR2 Q13324 1/20 0.35
KEAP1 Q14145 1/20 0.35
NFE2L2 Q16236 1/20 0.35
HPGD P15428 2/20 0.34
HIF1A Q16665 2/20 0.34
TP53 P04637 1/20 0.34
KDM4E B2RXH2 3/20 0.33
MAPT P10636 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2413972 0.86 ALDH1A1 (0.32) MAPK1ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL2409240 0.86 ALDH1A1 (0.32) MAPK1ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL22635781 0.86 MAPK1 (0.57) MAPK1ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL25401444 0.85 ALDH1A1 (0.33) MAPK1ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL2409154 0.81
SCHEMBL18221915 0.81 ALDH1A1 (0.31) ALDH1A1HSD17B10CRHBPCRHR2KEAP1
SCHEMBL2414392 0.81
SCHEMBL2407054 0.80 ALDH1A1 (0.34) MAPK1ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL2411093 0.79 ALDH1A1 (0.33) MAPK1ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL28765806 0.76 MLNR (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 891 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12041848-B2 Heterocyclic compound and organic light emitting element comprising same LG CHEM, LTD. (KR) 2024-07-16 US claimed
EP-3378853-B1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME LG CHEMICAL LTD (KR) 2024-04-17 EP claimed
US-11877509-B2 Organic light-emitting element LG CHEM, LTD. 2024-01-16 US claimed
US-20230322695-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE BRISTOL-MYERS SQUIBB COMPANY 2023-10-12 US claimed
WO-2023147531-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE BRISTOL-MYERS SQUIBB COMPANY (US) 2023-08-03 WO claimed
CN-115557879-A Compound and organic electronic device comprising the same 株式会社LG化学 2023-01-03 CN claimed
CN-108368077-B Heterocyclic compound and organic light-emitting device comprising same 株式会社LG化学 2022-07-05 CN claimed
CN-107501244-B Aromatic heterocyclic derivative, material for organic electroluminescent element, and organic electroluminescent element 出光兴产株式会社 2022-05-03 CN claimed
CN-107556298-B Aromatic heterocyclic derivative, material for organic electroluminescent element, and organic electroluminescent element 出光兴产株式会社 2021-12-21 CN claimed
CN-108699074-B Compound of spiro structure and organic electronic device comprising the same 株式会社LG化学 2021-12-14 CN claimed
US-20160020403-A1 ORGANIC ELECTROLUMINESCENT DEVICE USING ARYL AMINE DERIVATIVE CONTAINING HETEROCYCLE IDEMITSU KOSAN CO., LTD. (JP) 2016-01-21 US claimed
EP-2418707-B1 ORGANIC ELECTROLUMINESCENT ELEMENT AND MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT IDEMITSU KOSAN CO (JP) 2014-11-26 EP claimed
EP-2418707-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AND MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT Idemitsu Kosan Co., Ltd. (JP) 2012-02-15 EP claimed
US-8039127-B2 Organic electroluminescence device and material for organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2011-10-18 US claimed
US-8039129-B2 Organic electroluminescence device and material for organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2011-10-18 US claimed
US-20100258791-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-10-14 US claimed
US-20100253211-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2010-10-07 US claimed
US-7663304-B2 impact resistance IDEMITSU KOSAN CO., LTD. (JP) 2010-02-16 US claimed
US-4803222-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1989-02-07 US claimed
US-4720587-A ANTITUMOR AGENTS BURROUGHS WELLCOME CO. (US) 1988-01-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230322695-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE PTPN2, PTPN22, PTPN5 MAPK1 634/4885ALDH1A1 3033/4885TSHR 2969/4885
US-12041848-B2 Heterocyclic compound and organic light emitting element comprising same CRY1, CRY2, NR2E3 MAPK1 3622/4885ALDH1A1 242/4885TSHR 3741/4885
US-11877509-B2 Organic light-emitting element CRY1, CRY2, NR2E3 MAPK1 4606/4885ALDH1A1 567/4885TSHR 2662/4885
US-20160020403-A1 ORGANIC ELECTROLUMINESCENT DEVICE USING ARYL AMINE DERIVATIVE CONTAINING HETEROCYCLE SLC18A1, SLC18A2, AOC2 MAPK1 754/4885ALDH1A1 171/4885TSHR 2393/4885
US-20100258791-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE L1CAM, LEF1, LIMK1 MAPK1 712/4885ALDH1A1 222/4885TSHR 4057/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.