Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | NPC1 | O15118 | 2/20 | 0.76 |
| ▸ | RAB9A | P51151 | 2/20 | 0.76 |
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | NSD2 | O96028 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | PKM | P14618 | 1/20 | 0.76 |
| ▸ | APEX1 | P27695 | 1/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185813 | 1.00 | ALDH1A1 (0.76) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5431119 | 0.95 | LMNA (0.69) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5431117 | 0.95 | LMNA (0.69) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5092042 | 0.92 | MAOA (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL5092038 | 0.92 | MAOA (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL30027329 | 0.92 | LMNA (0.66) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL10601172 | 0.89 | LMNA (0.62) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15952288 | 0.89 | LMNA (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15952287 | 0.89 | LMNA (0.67) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL15952536 | 0.88 | LMNA (0.61) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260185-B | Deuterated derivative of corydaline and stephanine and preparation method thereof | 杨征 | 2024-09-24 | — | — | CN | disclosed |
| CN-115260185-A | Deuterated derivatives of corydaline and stepholidine and preparation method thereof | 杨征 | 2022-11-01 | — | — | CN | disclosed |
| EP-3438108-B1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-08-10 | — | — | EP | disclosed |
| EP-2848617-B1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-01-12 | — | — | EP | disclosed |
| CN-109071541-B | Phenyl [ a ] indole [2,3-g ] quinolizine compound, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2021-06-18 | — | — | CN | disclosed |
| US-10927107-B2 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-02-23 | — | — | US | disclosed |
| US-20190194185-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-06-27 | — | — | US | disclosed |
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
| EP-3438108-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2019-02-06 | — | — | EP | disclosed |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | Prosetta Antiviral, Inc. (US) | 2019-02-05 | — | — | US | disclosed |
| US-8552028-B2 | 8-phenylisoquinolines and pharmaceutical composition used in treatment for sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-10-08 | — | — | US | disclosed |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | NATIONAL TAIWAN UNIVERSITY (TW) | 2013-03-07 | — | — | US | disclosed |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| EP-1765796-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | Pfizer Products Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| WO-2006003495-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2006-01-12 | — | — | WO | disclosed |
| US-6762321-B2 | SUCH AS N-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-DIFLUOROMETHOXY-2-(4 -METHYLPHENYL)ACRYLAMIDE; FUNGICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-07-13 | — | — | US | disclosed |
| US-20030195354-A1 | Amide compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-10-16 | — | — | US | disclosed |
| EP-1295868-A1 | AMIDE COMPOUNDS AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-4001244-A | 1-ARYL-3,4-DIHYDRO-2(1H)-ISOQUINOLINE CARBONYL CHLORIDES | G. D. SEARLE & CO. (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | ALDH1A1 3748/4885LMNA 3070/4885MAPT 1106/4885 |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | ALDH1A1 2664/4885LMNA 317/4885MAPT 1858/4885 |
| US-10927107-B2 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof | PCSK9, PCSK7, PCSK6 | ALDH1A1 2606/4885LMNA 474/4885MAPT 2825/4885 |
| US-20130059882-A1 | 8-Phenylisoquinolines And Pharmaceutical Composition Used In Treatment For Sepsis | CXCL8, THPO, IL18 | ALDH1A1 2998/4885LMNA 2299/4885MAPT 1880/4885 |
| US-10195189-B2 | 2-phenethenyltetrahydro isoquinolines useful as anti-HIV compounds | MAVS, EIF2AK2, POLRMT | ALDH1A1 3748/4885LMNA 3070/4885MAPT 1106/4885 |
| US-20190194185-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | PCSK9, PCSK7, PCSK6 | ALDH1A1 2606/4885LMNA 474/4885MAPT 2825/4885 |
| US-20030195354-A1 | Amide compounds and use thereof | CBR1, CBR3, NAT1 | ALDH1A1 244/4885LMNA 3535/4885MAPT 3676/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | ALDH1A1 2956/4885LMNA 319/4885MAPT 1786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.