Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594333 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL1421327 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL20496747 | 0.86 | MAPK1 (0.55) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27831975 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL21639569 | 0.85 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL20496749 | 0.85 | ALDH1A1 (0.64) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4909115 | 0.84 | CYP2A13 (0.55) | ALDH1A1HPGDALOX15HSD17B10KMT2A | |
| SCHEMBL2781032 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL221971 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL2252952 | 0.82 | ALDH1A1 (0.61) | SMN1; SMN2MAPK1HCRTR1HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10857155-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2020-12-08 | — | — | US | disclosed |
| US-10406165-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | BIOTHERYX, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| WO-2018169777-A1 | COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. (US) | 2018-09-20 | — | — | WO | disclosed |
| US-20180264000-A1 | COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | BIOTHERYX, INC. | 2018-09-20 | — | — | US | disclosed |
| US-20080076760-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | WAKAMOTO PHARMACEUTICAL CO., LTD (JP) | 2008-03-27 | — | — | US | disclosed |
| EP-1820799-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | Wakamoto Pharmaceutical Co., Ltd. (JP) | 2007-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076760-A1 | 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION | GABRA5, GABRA1, GABRB1 | SMN1; SMN2 2287/4885MAPK1 1327/4885HCRTR1 2600/4885 |
| US-20180264000-A1 | COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF | GSPT1, GSPT2, GGT1 | SMN1; SMN2 517/4885MAPK1 1882/4885HCRTR1 1623/4885 |
| US-10857155-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | GSPT1, GSPT2, GGT1 | SMN1; SMN2 517/4885MAPK1 1882/4885HCRTR1 1623/4885 |
| US-10406165-B2 | Compounds targeting proteins, compositions, methods, and uses thereof | GSPT1, GSPT2, GGT1 | SMN1; SMN2 517/4885MAPK1 1882/4885HCRTR1 1623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.