Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.71 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.71 |
| ▸ | CES1 | P23141 | 2/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 4/20 | 0.63 |
| ▸ | CASP7 | P55210 | 3/20 | 0.63 |
| ▸ | CASP6 | P55212 | 3/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | CASP4 | P49662 | 1/20 | 0.63 |
| ▸ | CASP9 | P55211 | 1/20 | 0.63 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.63 |
| ▸ | CTRC | Q99895 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16798714 | 0.83 | ALDH3A1 (1.00) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| Hydrochloric Acid SCHEMBL9094768 | 0.82 | DRD2 (0.61) | ALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL4735891 | 0.82 | CHRM5 (0.68) | CA12CA1CA2CA9CASP3 | |
| SCHEMBL578265 | 0.82 | PARK7 (0.74) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| SCHEMBL15215078 | 0.82 | ALDH1A1 (0.71) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| SCHEMBL578250 | 0.82 | ACHE (0.74) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| SCHEMBL2008621 | 0.82 | ALDH1A1 (0.74) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| SCHEMBL5659265 | 0.82 | ALDH1A1 (1.00) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| SCHEMBL4786496 | 0.81 | CES1 (0.77) | ALDH1A1ALDH2ALDH3A1CES1CHRM1 | |
| SCHEMBL18955172 | 0.81 | CTRC (0.54) | ALDH1A1ALDH2ALDH3A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| US-9828342-B2 | Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof | CITY OF HOPE (US) | 2017-11-28 | — | — | US | disclosed |
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2013-08-29 | — | — | US | disclosed |
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2013-08-29 | — | — | US | disclosed |
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2013-08-29 | — | — | US | disclosed |
| US-20080004274-A1 | Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-01-03 | — | — | US | disclosed |
| EP-1828124-A1 | BIAROMATIC COMPOUNDS THAT MODULATE PPAR TYPE RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | Galderma Research & Development (FR) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063863-A1 | BIAROMATIC COMPOUNDS THAT MODULATE PPAR TYPE RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225637-A1 | ISATIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF | JAK2, ERBB2, CDC25C | ALDH1A1 3829/4885ALDH2 2913/4885ALDH3A1 4290/4885 |
| US-20080004274-A1 | Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof | PPARG, PPARD, PPARA | ALDH1A1 420/4885ALDH2 227/4885ALDH3A1 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.