SCHEMBL491001

SCHEMBL491001

c1ccc(CSc2ccc(C3=NC(c4ccc(SCc5ccccc5)cc4)(C4(c5ccc(SCc6ccccc6)cc5)N=C(c5ccc(SCc6ccccc6)cc5)C(c5ccc(SCc6ccccc6)cc5)=N4)N=C3c3ccc(SCc4ccccc4)cc3)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.45
MAOB P27338 3/20 0.45
HAO1 Q9UJM8 1/20 0.43
SLC6A4 P31645 1/20 0.42
ALOX5 P09917 1/20 0.40
PTGS1 P23219 1/20 0.40
HSD17B10 Q99714 1/20 0.39
PPARG P37231 1/20 0.37
PPARA Q07869 1/20 0.37
CYP3A4 P08684 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SCN9A Q15858 1/20 0.36
LTA4H P09960 1/20 0.36
PRMT5 O14744 1/20 0.36
EGFR P00533 1/20 0.36
POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2519476 0.78 MAOA (0.37) MAOAMAOBSLC6A4ALOX5HSD17B10
SCHEMBL6076179 0.75 MAOA (0.60) MAOAMAOBHAO1SLC6A4HSD17B10
SCHEMBL8666419 0.73 PTGS2 (0.45) PTGS1CYP3A4NPC1RAB9A
SCHEMBL490735 0.72 ALDH1A1 (0.41) HSD17B10CYP3A4NPC1RAB9A
SCHEMBL491053 0.71 ALDH1A1 (0.39) NPC1RAB9A
SCHEMBL332623 0.71 MAOA (0.63) MAOAMAOBHAO1SLC6A4HSD17B10
SCHEMBL5317061 0.69 HAO1 (0.56) MAOAMAOBHAO1SLC6A4ALOX5
SCHEMBL28084553 0.69 MAOA (0.61) MAOAMAOBHAO1SLC6A4HSD17B10
SCHEMBL14685048 0.68 NPC1 (0.55) MAOAMAOBHAO1SLC6A4HSD17B10
SCHEMBL14973574 0.67 NPC1 (0.41) NPC1RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8652759-B2 Processing of lithographic printing plates with a developer solution containing a hydrophilic polymer EASTMAN KODAK COMPANY (US) 2014-02-18 US disclosed
EP-1849600-B1 Bakeable radiation-sensitive elements with a high resistance to chemicals EASTMAN KODAK CO (US) 2013-12-11 EP disclosed
US-8507181-B2 Method for developing and sealing of lithographic printing plates KODAK (NEAR EAST) INC. 2013-08-13 US disclosed
US-8137891-B2 Bakeable lithographic printing plates with a high resistance to chemicals EASTMAN KODAK COMPANY (US) 2012-03-20 US disclosed
US-8119331-B2 Photopolymer composition usable for lithographic plates KODAK GRAPHIC COMMUNICATIONS GMBH (DE) 2012-02-21 US disclosed
US-8105755-B2 Method for processing of photopolymer printing plates with overcoat EASTMAN KODAK COMPANY (US) 2012-01-31 US disclosed
US-20110223540-A1 GUMMING COMPOSITIONS WITH NANO-PARTICLES FOR IMPROVING SCRATCH SENSITIVITY IN IMAGE AND NON-IMAGE AREAS OF LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK COMPANY 2011-09-15 US disclosed
EP-2217450-B1 PROCESSING OF LITHOGRAPHIC PRINTING PLATES WITH HYDROPHILIC POLYMER IN FINISHER SOLUTION EASTMAN KODAK CO (US) 2011-06-15 EP disclosed
US-7955776-B2 Light sensitive elements comprising substrates having coatings comprising photoinitiators or sensitizers, biuret structural and phosphazene oligomers, having improved photosensitivity, storage stability and wear resistance; photolithography EASTMAN KODAK COMPANY (US) 2011-06-07 US disclosed
EP-1868036-B1 Method for processing of photopolymer printing plates with overcoat EASTMAN KODAK CO (US) 2010-09-22 EP disclosed
US-20070142490-A1 Radiation-sensitive compositions and imageable elements based thereon BAUMANN HARALD 2007-06-21 US disclosed
WO-2007009580-A2 PHOTOPOLYMER COMPOSITION SUITABLE FOR LITHOGRAPHIC PRINTING PLATES EASTMAN KODAK COMPANY (US) 2007-01-25 WO disclosed
US-20060154169-A1 Radiation-sensitive compositions comprising a 1,4-dihydropyridine sensitizer and imageable elements based thereon KODAK POLYCHROME GRAPHICS GMBH (DE) 2006-07-13 US disclosed
WO-2006044243-A2 HOLOGRAPHIC STORAGE MEDIUM GENERAL ELECTRIC COMPANY A CORPORATION OF THE STATE OF NEW YORK (US) 2006-04-27 WO disclosed
US-20060078802-A1 Holographic storage medium SABIC INNOVATIVE PLASTICS IP B.V. 2006-04-13 US disclosed
US-20060063101-A1 Radiation-sensitive elements KODAK POLYCHROME GRAPHICS LLC (US) 2006-03-23 US disclosed
EP-1586006-A1 RADIATION-SENSITIVE ELEMENTS Kodak Polychrome Graphics GmbH (DE) 2005-10-19 EP disclosed
WO-2004111731-A1 RADIATION-SENSITIVE COMPOSITIONS COMPRISING A 1,4-DIHYDROPYRIDINE SENSITIZER AND IMAGEABLE ELEMENTS BASED THEREON KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-12-23 WO disclosed
WO-2004049068-A1 RADIATION-SENSITIVE ELEMENTS KODAK POLYCHROME GRAPHICS GMBH (DE) 2004-06-10 WO disclosed
US-4017313-A Photosensitive composition containing a leuco dye, a photosensitizer, an aromatic aldehyde and a secondary or tertiary amine and the use thereof in a direct-print process E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-04-12 US disclosed