Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918061 | 0.88 | NR4A2 (0.46) | OGFRL1OPRM1OPRD1OPRK1NR4A2 | |
| SCHEMBL4909486 | 0.86 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19OGFRL1 | |
| SCHEMBL4918658 | 0.82 | NR4A2 (0.45) | OGFRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL4915316 | 0.81 | HDAC3 (0.55) | OGFRL1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL4920409 | 0.80 | OPRM1 (0.45) | OGFRL1OPRM1OPRD1OPRK1NR4A2 | |
| SCHEMBL4910139 | 0.79 | NR4A2 (0.44) | OGFRL1OPRM1OPRD1OPRK1NR4A2 | |
| SCHEMBL15576001 | 0.76 | GSK3B (0.47) | OGFRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL4916973 | 0.76 | OPRM1 (0.57) | OGFRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL6161817 | 0.73 | CYP11B2 (0.60) | OGFRL1OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL9685823 | 0.73 | RPS6KB1 (0.47) | CYP1A2CYP2D6OGFRL1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058376-A1 | PIPERIDINES | ICAGEN, INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-7244744-B2 | Piperidines | ICAGEN, INC. (US) | 2007-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058376-A1 | PIPERIDINES | TRPV3, SCN3A, TRPV1 | CYP1A2 3200/4885CYP3A4 3795/4885CYP2D6 3504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.