SCHEMBL491032

SCHEMBL491032

O=c1cc(-c2ccc(O)c(O)c2)oc2ccc(O)cc12

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 4/20 0.78
POLH Q9Y253 4/20 0.78
TNKS O95271 3/20 0.78
PARP1 P09874 3/20 0.78
TNKS2 Q9H2K2 3/20 0.78
MAPT P10636 8/20 0.77
CYP3A4 P08684 7/20 0.77
HPGD P15428 5/20 0.77
SMN1; SMN2 Q16637 5/20 0.77
IP6K2 Q9UHH9 5/20 0.77
TP53 P04637 4/20 0.77
NPC1 O15118 4/20 0.77
ALOX15 P16050 4/20 0.77
RAB9A P51151 3/20 0.77
LMNA P02545 2/20 0.77
THRB P10828 2/20 0.77
CASP3 P42574 1/20 0.77
SENP8 Q96LD8 1/20 0.77
SENP7 Q9BQF6 1/20 0.77
SENP6 Q9GZR1 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30591365 1.00 ALOX5 (0.78) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL29664594 1.00 ALOX5 (0.78) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL29678122 0.88 TNKS (1.00) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL34405 0.88 TNKS (1.00) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL31387554 0.88 CYP3A4 (0.75) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL311405 0.87 MAPT (1.00) TNKSMAPTCYP3A4HPGDSMN1; SMN2
SCHEMBL31741263 0.87 MAPT (1.00) TNKSMAPTCYP3A4HPGDSMN1; SMN2
SCHEMBL12378837 0.86 PTPRS (0.78) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL2218499 0.86 POLH (0.75) ALOX5POLHTNKSPARP1TNKS2
SCHEMBL31387550 0.84 MAPT (0.74) ALOX5POLHTNKSPARP1TNKS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240122894-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2024-04-18 US claimed
EP-4259614-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF National University of Singapore (SG) 2023-10-18 EP claimed
CN-116829544-A Synthesis method of flavonoid dimers and oligomers and application thereof 新加坡国立大学 2023-09-29 CN claimed
WO-2022124994-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2022-06-16 WO claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
EP-1435930-A2 ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2004-07-14 EP claimed
WO-2003032969-A2 ANTI-GLYCATION AGENTS FOR PREVENTING AGE-, DIABETES-, AND SMOKING-RELATED COMPLICATIONS NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2003-04-24 WO claimed
JP-2003504327-A 2003-02-04 JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
US-20240122894-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2024-04-18 US disclosed
EP-4259614-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF National University of Singapore (SG) 2023-10-18 EP disclosed
CN-116829544-A Synthesis method of flavonoid dimers and oligomers and application thereof 新加坡国立大学 2023-09-29 CN disclosed
WO-2022124994-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2022-06-16 WO disclosed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed
US-6555523-B1 Such as 3',4'-diacetoxy-5,6,7-trimethoxyflavone or naringin in the treatment HIV, picornavirus, and/or respiratory virus CASCADE ESTATES LTD. (MU) 2003-04-29 US disclosed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 EP disclosed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240122894-A1 METHODS TO SYNTHESIZE FLAVONOID DIMERS AND OLIGOMERS AND THE USE THEREOF ERG28, MGAM, CTRB2 ALOX5 2223/4885POLH 856/4885TNKS 3615/4885
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP ALOX5 590/4885POLH 1729/4885TNKS 2038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.