SCHEMBL491173

SCHEMBL491173

Clc1ccc(C2=NC(c3ccccc3Br)(C3(c4ccccc4Br)N=C(c4ccc(Cl)cc4Cl)C(c4ccc(Cl)cc4Cl)=N3)N=C2c2ccc(Cl)cc2Cl)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.37
RAB9A P51151 5/20 0.37
HPGD P15428 4/20 0.37
SMN1; SMN2 Q16637 4/20 0.37
ALDH1A1 P00352 3/20 0.37
HSD17B10 Q99714 2/20 0.37
TSHR P16473 2/20 0.37
TP53 P04637 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSD11B1 P28845 3/20 0.35
AHR P35869 1/20 0.35
PDK2 Q15119 1/20 0.35
CRHR1 P34998 3/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
DPP4 P27487 1/20 0.34
MAPT P10636 2/20 0.34
PKM P14618 1/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490759 0.86 SMN1; SMN2 (0.40) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL6298557 0.83 HSP90AA1 (0.40) NPC1RAB9ASMN1; SMN2ALDH1A1TSHR
SCHEMBL491055 0.80 AHR (0.41) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL490732 0.73 GABRA1 (0.36) SMN1; SMN2PDK2KMT2AMAPT
SCHEMBL16424727 0.71 AHR (0.45) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL80409 0.70 ALDH1A1 (0.40) NPC1RAB9ASMN1; SMN2ALDH1A1TSHR
SCHEMBL1425804 0.70 CYP2A6 (0.40) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL80380 0.68 CHRM1 (0.41) NPC1RAB9AHPGDSMN1; SMN2ALDH1A1
SCHEMBL18037939 0.65 CYP1A2 (0.45) NPC1RAB9ASMN1; SMN2ALDH1A1TSHR
SCHEMBL491334 0.65 HTR2A (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8652759-B2 Processing of lithographic printing plates with a developer solution containing a hydrophilic polymer EASTMAN KODAK COMPANY (US) 2014-02-18 US disclosed
US-8632937-B2 UV-sensitive lithographic printing plate precursor with benzoxazole derivative and analogues thereof as sensitizer EASTMAN KODAK COMPANY (US) 2014-01-21 US disclosed
EP-1849600-B1 Bakeable radiation-sensitive elements with a high resistance to chemicals EASTMAN KODAK CO (US) 2013-12-11 EP disclosed
US-8507181-B2 Method for developing and sealing of lithographic printing plates KODAK (NEAR EAST) INC. 2013-08-13 US disclosed
US-8361701-B2 Method for making lithographic plates EASTMAN KODAK COMPANY (US) 2013-01-29 US disclosed
EP-2293144-B1 Method of drying lithographic printing plates after single-step-processing EASTMAN KODAK CO (US) 2012-11-07 EP disclosed
US-20120152139-A1 METHOD AND APPARATUS FOR DRYING AFTER SINGLE-STEP-PROCESSING OF LITHOGRAPHIC PRINTING PLATES QUALEX INC. 2012-06-21 US disclosed
US-8137891-B2 Bakeable lithographic printing plates with a high resistance to chemicals EASTMAN KODAK COMPANY (US) 2012-03-20 US disclosed
US-8119331-B2 Photopolymer composition usable for lithographic plates KODAK GRAPHIC COMMUNICATIONS GMBH (DE) 2012-02-21 US disclosed
US-8105755-B2 Method for processing of photopolymer printing plates with overcoat EASTMAN KODAK COMPANY (US) 2012-01-31 US disclosed
EP-0756204-B1 Photopolymerizable composition and photosensitive lithographic printing plate employing it MITSUBISHI CHEM CORP (JP) 2000-09-20 EP disclosed
US-5800965-A LIGHT SENSITIVE LITHOGRAPHIC PLATES AND ADDITION POLYMERIZABLE MONOMERS AND PHOSPHORIC ACID DERIVATIVES MITSUBISHI CHEMICAL CORPORATION (JP) 1998-09-01 US disclosed
EP-0851299-A1 Photosensitive lithographic printing plate MITSUBISHI CHEMICAL CORPORATION (JP) 1998-07-01 EP disclosed
US-5723260-A LIGHT SENSITIVE ELEMENTS AND STORAGE STABILITY MITSUBISHI CHEMICAL CORPORATION (JP) 1998-03-03 US disclosed
US-5686231-A Process for disposing of developer for pigment-containing non-silver-salt photo sensitive material, apparatus therefor and automatic developing system MITSUBISHI CHEMICAL CORPORATION (JP) 1997-11-11 US disclosed
EP-0793145-A1 Photopolymerizable composition for a photosensitive lithographic printing plate and photosensitive lithographic printing plate employing it MITSUBISHI CHEMICAL CORPORATION (JP) 1997-09-03 EP disclosed
EP-0763779-A2 Unsaturated group-containing urethane compound, photopolymerizable composition containing it, and photosensitive lithographic printing plate Mitsubishi Chemical Corporation (JP) 1997-03-19 EP disclosed
EP-0756204-A1 Photopolymerizable composition and photosensitive lithographic printing plate employing it MITSUBISHI CHEMICAL CORPORATION (JP) 1997-01-29 EP disclosed
EP-0747773-A1 METHOD AND APPARATUS FOR TREATING DEVELOPER FOR PIGMENT-CONTAINING NONSILVER PHOTOSENSITIVE MATERIAL, AND AUTOMATIC DEVELOPING MACHINE MITSUBISHI CHEMICAL CORPORATION (JP) 1996-12-11 EP disclosed
EP-0738929-A2 Photopolymerizable sensitive material Mitsubishi Chemical Corporation (JP) 1996-10-23 EP disclosed