Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29756 | 0.98 | HPGDS (0.43) | HPGDSBAZ2AAOC3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15717196 | 0.98 | HPGDS (0.43) | HPGDSBAZ2AAOC3MEN1KMT2A | |
| SCHEMBL23378641 | 0.94 | HPGDS (0.40) | HPGDSBAZ2AAOC3MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL18978992 | 0.88 | AOC3 (0.42) | HPGDSBAZ2AAOC3MEN1KMT2A | |
| SCHEMBL1064089 | 0.88 | HTR2B (0.39) | HPGDSBAZ2AHTR2BMAPTSLC6A3 | |
| SCHEMBL3687239 | 0.83 | HPGDS (0.44) | HPGDSBAZ2AAOC3MEN1KMT2A | |
| SCHEMBL3555706 | 0.81 | HTR2B (0.35) | HTR2BMAPTSLC6A3 | |
| SCHEMBL3572530 | 0.79 | HTR2B (0.33) | HTR2BMAPTSLC6A3 | |
| SCHEMBL15746407 | 0.78 | PLG (0.36) | BAZ2AHTR2BPLGMAPT | |
| SCHEMBL15747122 | 0.78 | HTR2B (0.33) | HTR2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271405-B1 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2013-07-24 | — | — | EP | claimed |
| US-20110060007-A1 | Novel NIP Thiazole Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydroge-Nase-1 | Merck Patent Gesellschaft Mit Beschrankter Haftling (DE) | 2011-03-10 | — | — | US | claimed |
| EP-2271405-A2 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDORXYSTEROID DEHYDROGENASE-1 | Merck Patent GmbH (DE) | 2011-01-12 | — | — | EP | claimed |
| WO-2009135581-A9 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2010-11-11 | — | — | WO | claimed |
| WO-2009135581-A2 | NOVEL NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2009-11-12 | — | — | WO | claimed |
| US-11274076-B2 | Process for preparing 1, 2-benzenedimethanol compound | GOWAN COMPANY, L.L.C. (US) | 2022-03-15 | — | — | US | disclosed |
| US-20200399263-A1 | PROCESS FOR PREPARING 1, 2-BENZENEDIMETHANOL COMPOUND | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT | 2020-12-24 | — | — | US | disclosed |
| EP-3679035-A1 | NOVEL FUNGICIDAL HETEROCYCLIC COMPOUNDS | PI Industries Ltd. (IN) | 2020-07-15 | — | — | EP | disclosed |
| WO-2019048989-A1 | NOVEL FUNGICIDAL HETEROCYCLIC COMPOUNDS | PI INDUSTRIES LTD. (IN) | 2019-03-14 | — | — | WO | disclosed |
| EP-3181563-B1 | CONDENSED 11-MEMBER RING COMPOUND AND AGRICULTURE AND HORTICULTURAL FUNGICIDE COMPRISING SAME | SDS BIOTECH CORP (JP) | 2019-02-06 | — | — | EP | disclosed |
| WO-2018193387-A1 | HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES | PI INDUSTRIES LTD. (IN) | 2018-10-25 | — | — | WO | disclosed |
| US-10104891-B2 | Fused 11-membered compounds and agricultural/horticultural fungicides containing them | SDS BIOTECH K.K. (JP) | 2018-10-23 | — | — | US | disclosed |
| CN-101888843-A | Fungicidal azacyclic amides | DU PONT | 2010-11-17 | — | — | CN | disclosed |
| WO-2009135581-A9 | NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2010-11-11 | — | — | WO | disclosed |
| EP-2187748-A2 | FUNGICIDAL COMPOUNDS AND MIXTURES | E. I. du Pont de Nemours and Company (US) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009135581-A2 | NOVEL NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK PATENT GMBH (DE) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009055514-A2 | FUNGICIDAL MIXTURES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-04-30 | — | — | WO | disclosed |
| EP-2049111-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008013925-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008013622-A2 | FUNGICIDAL AZOCYCLIC AMIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060007-A1 | Novel NIP Thiazole Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydroge-Nase-1 | HSD11B1, HSD17B1, HSD11B2 | HPGDS 32/4885BAZ2A 4597/4885AOC3 3787/4885 |
| US-20200399263-A1 | PROCESS FOR PREPARING 1, 2-BENZENEDIMETHANOL COMPOUND | ADH1A, ADH1C, CYP2E1 | HPGDS 2179/4885BAZ2A 1038/4885AOC3 144/4885 |
| US-10104891-B2 | Fused 11-membered compounds and agricultural/horticultural fungicides containing them | CYP51A1, CYP4Z1, ERG28 | HPGDS 4553/4885BAZ2A 745/4885AOC3 1357/4885 |
| US-11274076-B2 | Process for preparing 1, 2-benzenedimethanol compound | ADH1A, ADH1C, CYP2E1 | HPGDS 2179/4885BAZ2A 1038/4885AOC3 144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.