Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | RAD52 | P43351 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 2/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4913166 | 0.77 | HTR1A (0.73) | NCF1SLC2A1POLBRAD52KDM4E | |
| SCHEMBL4912004 | 0.75 | ALDH1A1 (0.45) | NCF1SLC2A1POLBALDH1A1KMT2A | |
| SCHEMBL899153 | 0.75 | NCF1 (1.00) | NCF1SLC2A1POLBRAD52KDM4E | |
| SCHEMBL9616073 | 0.74 | CYP1A2 (0.53) | ALDH1A1ACP1NPC1RAB9AHRH3 | |
| SCHEMBL18879049 | 0.73 | GPR3 (0.44) | NCF1SLC2A1KDM4EALDH1A1NPC1 | |
| SCHEMBL12402667 | 0.72 | SLC2A1 (1.00) | NCF1SLC2A1POLBRAD52KDM4E | |
| SCHEMBL237848 | 0.72 | RET (0.39) | NCF1SLC2A1POLBRAD52KDM4E | |
| SCHEMBL20265361 | 0.70 | ALDH1A1 (0.47) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL19841858 | 0.69 | IDO1 (0.43) | KDM4EALDH1A1ACP1NPC1RAB9A | |
| SCHEMBL11669132 | 0.69 | CA12 (0.61) | NCF1SLC2A1POLBRAD52KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-6992089-B2 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE UNIVERSITY OF NEW JERSEY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-27 | — | — | US | disclosed |
| WO-2004014906-A2 | NITRO AND AMINO SUBSTITUTED DIBENZONAPHTHYRIDINES AS TOPOISOMERASE AGENTS | RUTGERS, THE STATE UNIVERSITY (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | NCF1 250/4885SLC2A1 3449/4885POLB 30/4885 |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | NCF1 159/4885SLC2A1 3228/4885POLB 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.