Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493561 | 0.92 | SMYD3 (0.48) | EPHX2EPHX1OPRM1OPRL1SIGMAR1 | |
| SCHEMBL493559 | 0.90 | EPHX2 (0.43) | EPHX2EPHX1OPRM1OPRL1SIGMAR1 | |
| SCHEMBL492989 | 0.86 | RAB9A (0.43) | EPHX2EPHX1OPRM1OPRL1ALDH1A1 | |
| SCHEMBL493829 | 0.84 | L3MBTL1 (0.43) | EPHX2EPHX1OPRM1OPRL1SIGMAR1 | |
| SCHEMBL493719 | 0.82 | ATF4 (0.60) | ALDH1A1HTT | |
| SCHEMBL1328539 | 0.80 | MCHR1 (0.54) | OPRM1SIGMAR1ALDH1A1 | |
| SCHEMBL493440 | 0.79 | TSHR (0.48) | ALDH1A1HTTMETAP2 | |
| SCHEMBL1327350 | 0.79 | KMT2A (0.47) | ALDH1A1 | |
| SCHEMBL2305482 | 0.78 | CTDSP1 (0.53) | SMYD3ALDH1A1HTT | |
| SCHEMBL493318 | 0.78 | CYP3A4 (0.47) | EPHX2OPRM1OPRL1MAOASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | EPHX2 2567/4885EPHX1 2483/4885OPRM1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.