Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.75 |
| ▸ | RAB9A | P51151 | 5/20 | 0.75 |
| ▸ | NPC1 | O15118 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493604 | 0.88 | SMN1; SMN2 (0.74) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL16437800 | 0.86 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL19380258 | 0.86 | RAB9A (0.73) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL16437799 | 0.84 | SMN1; SMN2 (0.75) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL31036198 | 0.82 | SMN1; SMN2 (0.72) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL19380060 | 0.81 | LMNA (0.74) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL15107378 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL15107386 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL29517825 | 0.80 | SMN1; SMN2 (0.73) | SMN1; SMN2RAB9ANPC1LMNAKMT2A | |
| SCHEMBL13438255 | 0.80 | SMN1; SMN2 (0.65) | SMN1; SMN2RAB9ANPC1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170066759-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2017-03-09 | — | — | US | disclosed |
| US-9499533-B2 | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity | SHIONOGI & CO., LTD. (JP) | 2016-11-22 | — | — | US | disclosed |
| US-20150038483-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-02-05 | — | — | US | disclosed |
| EP-2832731-A1 | AROMATIC HETEROCYCLIC FIVE-MEMBERED RING DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY | Shionogi & Co., Ltd. (JP) | 2015-02-04 | — | — | EP | disclosed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066759-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | TRPV4, TRPC4, TRPV2 | SMN1; SMN2 3980/4885RAB9A 1927/4885NPC1 971/4885 |
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | SMN1; SMN2 1729/4885RAB9A 2004/4885NPC1 519/4885 |
| US-20150038483-A1 | AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY | TRPV4, TRPC4, TRPV2 | SMN1; SMN2 3980/4885RAB9A 1927/4885NPC1 971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.