Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13304408 | 1.00 | CHRM2 (0.61) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL30463043 | 0.99 | ALDH1A1 (0.62) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL30463042 | 0.99 | ALDH1A1 (0.62) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL3339536 | 0.99 | ALDH1A1 (0.62) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL9720608 | 0.87 | CHRM2 (0.56) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Hydrochloric Acid SCHEMBL9720679 | 0.86 | ALDH1A1 (0.57) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL10859044 | 0.85 | CHRM2 (0.57) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL11031607 | 0.84 | CHRM2 (0.56) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL10847938 | 0.83 | CHRM2 (0.70) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL14021127 | 0.83 | SLC6A4 (0.54) | CHRM2ADRA2BDRD3SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372979-B2 | Process for the production of high-purity 2,4′-dimethyl-3-piperidino-propiophenone (tolperisone), pharmaceutical compositions that contain the latter, as well as active ingredient formulations that contain tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2013-02-12 | — | — | US | disclosed |
| US-20100150995-A1 | PROCESS FOR THE PRODUCTION OF HIGH-PURITY 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THE LATTER, AS WELL AS ACTIVE INGREDIENT FORMULATIONS THAT CONTAIN TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2010-06-17 | — | — | US | disclosed |
| US-20080188522-A1 | Method for producing salts of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-08-07 | — | — | US | disclosed |
| US-20080188522-A1 | Method for producing salts of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-08-07 | — | — | US | disclosed |
| US-20080188522-A1 | Method for producing salts of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-08-07 | — | — | US | disclosed |
| US-7385060-B2 | Method for producing salts of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-06-10 | — | — | US | disclosed |
| US-7385060-B2 | Method for producing salts of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-06-10 | — | — | US | disclosed |
| US-7385060-B2 | Method for producing salts of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-06-10 | — | — | US | disclosed |
| EP-1567510-B1 | METHOD FOR PRODUCING SALTS OF TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2006-12-20 | — | — | EP | disclosed |
| US-20060041141-A1 | Method for producing salts of tolperisone | Sanochemia Pharmazeutika GmbH (AT) | 2006-02-23 | — | — | US | disclosed |
| EP-1567510-A1 | METHOD FOR PRODUCING SALTS OF TOLPERISONE | Sanochemia Pharmazeutica Aktiengesellschaft (AT) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050648-A1 | METHOD FOR PRODUCING SALTS OF TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2004-06-17 | — | — | WO | disclosed |
| EP-0273375-B2 | Propiophenone derivatives for treatment of pollakiuria (frequency urination) | HOKURIKU PHARMACEUTICAL (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-4912116-A | Propiophenone derivatives for treatment of pollakiuria (frequency urination) | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188522-A1 | Method for producing salts of tolperisone | THOP1, DCTPP1, CYP21A2 | CHRM2 1387/4885ADRA2B 226/4885DRD3 515/4885 |
| US-20100150995-A1 | PROCESS FOR THE PRODUCTION OF HIGH-PURITY 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THE LATTER, AS WELL AS ACTIVE INGREDIENT FORMULATIONS THAT CONTAIN TOLPERISONE | MMP17, MMP25, MMP1 | CHRM2 258/4885ADRA2B 964/4885DRD3 1221/4885 |
| US-20060041141-A1 | Method for producing salts of tolperisone | CYP21A2, THOP1, DCTPP1 | CHRM2 1409/4885ADRA2B 196/4885DRD3 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.