Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951205 | 0.92 | ALDH1A1 (0.53) | ALDH1A1TSHRKMT2A | |
| SCHEMBL11665299 | 0.85 | HPGD (0.35) | ALDH1A1TSHRHPGDKMT2A | |
| SCHEMBL17495213 | 0.83 | CHRM2 (0.36) | TSHR | |
| SCHEMBL7714477 | 0.83 | CES1 (0.41) | ALDH1A1KMT2A | |
| SCHEMBL28191042 | 0.83 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| SCHEMBL2304429 | 0.82 | KMT2A (0.45) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL7947621 | 0.81 | ALDH1A1 (0.43) | ALDH1A1TSHRMEN1HPGDKMT2A | |
| SCHEMBL7950973 | 0.80 | KMT2A (0.48) | ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9581084 | 0.80 | TSHR (0.58) | ALDH1A1TSHRMEN1KMT2ARECQL | |
| SCHEMBL7563843 | 0.80 | KMT2A (0.48) | ALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419999-B2 | Gamma lactams as prostaglandin agonists and use thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2008-09-02 | — | — | US | disclosed |
| EP-1556347-A4 | GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS (AN) | 2006-08-09 | — | — | EP | disclosed |
| US-20050288357-A1 | Gamma lactams as prostaglandin agonists and use thereof | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-12-29 | — | — | US | disclosed |
| EP-1556347-A2 | GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003103604-A2 | GAMMA LACTAMS AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V (AN) | 2003-12-18 | — | — | WO | disclosed |
| US-5534547-A | Prostaglandins of the D series, and tranquilizers and soporifics containing the same | KABUSHIKI KAISHA UENO SEIYAKU OYO KENKYUJO (JP) | 1996-07-09 | — | — | US | disclosed |
| US-5428062-A | Side effect reduction | K.K. UENO SEIYAKU OYO KENKYUJO (JP) | 1995-06-27 | — | — | US | disclosed |
| US-5137915-A | PROSTAGLANDINS OF THE D SERIES, AND TRANQUILIZERS AND SOPORIFICS CONTAINING THE SAME | K.K. UENO SEIYAKU OYO KENKYUJO (JP) | 1992-08-11 | — | — | US | disclosed |
| EP-0281239-B1 | PROSTAGLANDINS OF THE D SERIES, AND TRANQUILIZERS AND SOPORIFICS CONTAINING THE SAME | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-5073569-A | 13,14-dihydro-15-keto- | K.K. UENO SEIYAKU OYO KENKYUJO (JP) | 1991-12-17 | — | — | US | disclosed |
| EP-0281239-A2 | Prostaglandins of the D series, and tranquilizers and soporifics containing the same | Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4113766-A | Oxaprostaglandins | PFIZER INC. (US) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288357-A1 | Gamma lactams as prostaglandin agonists and use thereof | PGF, HPGDS, PTGIS | ALDH1A1 1403/4885TSHR 2081/4885MEN1 3591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.