Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 known ✓ | P22748 | 4/20 | 0.79 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.53 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.47 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL18911550 | 1.00 | CA4 (0.79) | CA4CA1FAHD1FFAR3TSHR | |
| Pyruvate SCHEMBL28358508 | 0.96 | CA4 (0.77) | CA4CA1FAHD1FFAR3TSHR | |
| Pyruvate SCHEMBL27699044 | 0.94 | CA4 (0.69) | CA4CA1FAHD1FFAR3TSHR | |
| Pyruvate SCHEMBL31304104 | 0.89 | CA4 (0.85) | CA4CA1FAHD1FFAR3TSHR | |
| Pyruvate SCHEMBL22115985 | 0.89 | CA4 (0.85) | CA4CA1FAHD1FFAR3TSHR | |
| Pyruvate SCHEMBL17378159 | 0.89 | CA1 (0.69) | CA4CA1FAHD1FFAR3TSHR | |
| Pyruvate SCHEMBL1332812 | 0.89 | — | — | |
| Pyruvate SCHEMBL1332703 | 0.89 | — | — | |
| Pyruvate SCHEMBL1332722 | 0.89 | — | — | |
| Pyruvate SCHEMBL1333219 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120000814-A | Nerve center regulation experimental method for general anesthesia arousal and mental rewarding side effect | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | 2025-05-16 | — | — | CN | disclosed |
| CN-114698629-A | Cell storage device and cell storage method for optimizing cell preservation | 江苏真旺农业生物科技有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-103361305-A | Application of small molecule compound | ZHAO MENG | 2013-10-23 | — | — | CN | disclosed |
| EP-1709151-A4 | COMPOSITIONS AND METHODS FOR PROPAGATION OF NEURAL PROGENITOR CELLS | CATHOLIC HEALTHCARE WEST (US) | 2008-01-02 | — | — | EP | disclosed |
| EP-1709151-A2 | COMPOSITIONS AND METHODS FOR PROPAGATION OF NEURAL PROGENITOR CELLS | Catholic Healthcare West (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005056755-A2 | COMPOSITIONS AND METHODS FOR PROPAGATION OF NEURAL PROGENITOR CELLS | CATHOLIC HEALTHCARE WEST (US) | 2005-06-23 | — | — | WO | disclosed |