Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949763 | 0.84 | MAPK8 (0.41) | APPNPC1RAB9ASMN1; SMN2MAPK8 | |
| SCHEMBL4948593 | 0.82 | MAPK8 (0.55) | NPC1RAB9ASMN1; SMN2MAPK8MAPK9 | |
| SCHEMBL5596467 | 0.78 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2MAPK9MAPK10 | |
| SCHEMBL3745112 | 0.74 | MAPK10 (0.71) | NPC1RAB9ASMN1; SMN2MAPK8MAPK9 | |
| SCHEMBL5597097 | 0.72 | PTGS1 (0.40) | APPNPC1RAB9ASMN1; SMN2NOS1 | |
| SCHEMBL5596344 | 0.71 | RAB9A (0.46) | NPC1RAB9ASMN1; SMN2CDK5CDK5R1 | |
| SCHEMBL5596393 | 0.71 | KDM4E (0.36) | APPNPC1RAB9ASMN1; SMN2MAPK9 | |
| SCHEMBL4949279 | 0.69 | MGLL (0.43) | NPC1RAB9ASMN1; SMN2MGLLALDH1A1 | |
| SCHEMBL8397683 | 0.69 | APP (0.64) | APPNPC1RAB9ASMN1; SMN2LRRK2 | |
| SCHEMBL7144576 | 0.68 | ILK (0.50) | NPC1RAB9ASMN1; SMN2MGLLILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812072-B1 | BENZOTHIAZOLE FORMULATIONS AND USE THEREOF | ARES TRADING SA (CH) | 2008-10-22 | — | — | EP | disclosed |
| EP-1812072-A2 | BENZOTHIAZOLE FORMULATIONS AND USE THEREOF | Ares Trading S.A. (CH) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053882-A2 | BENZOTHIAZOLE FORMULATIONS AND USE THEREOF | ARES TRADING S.A. (CH) | 2006-05-26 | — | — | WO | disclosed |