Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | AHR | P35869 | 3/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21366075 | 0.82 | MAPT (0.58) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2028344 | 0.78 | GPR84 (1.00) | GPR84ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL21438815 | 0.77 | GPR84 (0.71) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1606455 | 0.77 | NPC1 (0.79) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL28444915 | 0.76 | GPR84 (0.59) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11924959 | 0.76 | RAB9A (1.00) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL21366050 | 0.76 | MAPT (0.60) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22644186 | 0.75 | MEN1 (0.66) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL21547896 | 0.75 | KMT2A (0.70) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL22462583 | 0.75 | MAPT (0.66) | GPR84MAPTALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116925066-A | Indole thiazole ketone compound and application thereof | 张所明 | 2023-10-24 | — | — | CN | disclosed |
| CN-116925066-A | Indole thiazole ketone compound and application thereof | 张所明 | 2023-10-24 | — | — | CN | disclosed |
| WO-2021127302-A1 | 2-(1H-INDOLE-3-CARBONYL)-THIAZOLE-4-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS | Ikena Oncology, Inc. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3191481-B1 | EFFICIENT AND SCALABLE SYSTHESIS OF 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER AND ITS STRUCTURAL ANALOGS | ARIAGEN INC (US) | 2020-11-25 | — | — | EP | disclosed |
| US-20190084948-A1 | Efficient and scalable synthesis of 2-(1'H-Indole-3'-Carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs | ARIAGEN, INC. (US) | 2019-03-21 | — | — | US | disclosed |
| US-10081610-B2 | Efficient and scalable synthesis of 2-(1′h-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs | ARIAGEN, INC. (US) | 2018-09-25 | — | — | US | disclosed |
| US-20170291881-A1 | EFFICIENT AND SCALABLE SYNTHESIS OF 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER AND ITS STRUCTURAL ANALOGS | AHR PHARMACEUTICALS, INC. (US) | 2017-10-12 | — | — | US | disclosed |
| CN-107001350-A | Effective and expansible synthesis of the carboxylate methyl ester of 2 (carbonyl of 1 ' H indoles 3 ') thiazole 4 and its analogue | AHR制药股份公司 | 2017-08-01 | — | — | CN | disclosed |
| EP-3191481-A1 | EFFICIENT AND SCALABLE SYSTHESIS OF 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER AND ITS STRUCTURAL ANALOGS | AHR Pharmaceuticals Inc. (US) | 2017-07-19 | — | — | EP | disclosed |
| CN-106588908-A | ITE for cancer intervention and eradication | 宋嘉声 | 2017-04-26 | — | — | CN | disclosed |
| US-7241900-B2 | Synthesis of indole thiazole compounds as ligands for the Ah receptor | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-07-10 | — | — | US | disclosed |
| US-20070043092-A1 | Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2007-02-22 | — | — | US | disclosed |
| CN-1915991-A | Synthesis of indole thiazole compounds as ligands for the ah receptor | WISCONSIN ALUMNI RES FOUND (US) | 2007-02-21 | — | — | CN | disclosed |
| US-20060079692-A1 | Synthesis of indole thiazole compounds as ligands for the Ah receptor | DELUCA HECTOR F | 2006-04-13 | — | — | US | disclosed |
| EP-1480951-A4 | SYNTHESIS OF INDOLE THIAZOLE COMPOUNDS AS LIGANDS FOR THE AH RECEPTOR | WISCONSIN ALUMNI RES FOUND (US) | 2006-03-22 | — | — | EP | disclosed |
| US-7002019-B2 | Synthesis of indole thiazole compounds as ligands for the Ah receptor | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-02-21 | — | — | US | disclosed |
| CN-1642910-A | Synthesis of indole thiazole compounds as ligands for the AH receptor | WISCONSIN ALUMNI RES FOUND (US) | 2005-07-20 | — | — | CN | disclosed |
| EP-1480951-A1 | SYNTHESIS OF INDOLE THIAZOLE COMPOUNDS AS LIGANDS FOR THE AH RECEPTOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20040204588-A1 | Synthesis of indole thiazole compounds as ligands for the Ah receptor | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2004-10-14 | — | — | US | disclosed |
| WO-2003068742-A1 | SYNTHESIS OF INDOLE THIAZOLE COMPOUNDS AS LIGANDS FOR THE AH RECEPTOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10081610-B2 | Efficient and scalable synthesis of 2-(1′h-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs | INMT, WEE1, WEE2 | GPR84 2962/4885MAPT 755/4885ALDH1A1 236/4885 |
| US-20070043092-A1 | Use of aryl hydrocarbon receptor ligand as a therapeutic intervention in angiogenesis-implicated disorders | VEGFA, NR1H2, ARNT | GPR84 282/4885MAPT 4787/4885ALDH1A1 526/4885 |
| US-20060079692-A1 | Synthesis of indole thiazole compounds as ligands for the Ah receptor | AHR, HCAR1, HCAR2 | GPR84 102/4885MAPT 4352/4885ALDH1A1 208/4885 |
| US-20190084948-A1 | Efficient and scalable synthesis of 2-(1'H-Indole-3'-Carbonyl)-thiazole-4-carboxylic acid methyl ester and its structural analogs | INMT, WEE1, IDO1 | GPR84 2961/4885MAPT 701/4885ALDH1A1 153/4885 |
| US-20170291881-A1 | EFFICIENT AND SCALABLE SYNTHESIS OF 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID METHYL ESTER AND ITS STRUCTURAL ANALOGS | INMT, WEE1, HADH | GPR84 2989/4885MAPT 766/4885ALDH1A1 234/4885 |
| US-20040204588-A1 | Synthesis of indole thiazole compounds as ligands for the Ah receptor | AHR, HCAR1, HCAR2 | GPR84 102/4885MAPT 4352/4885ALDH1A1 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.