SCHEMBL4950108

SCHEMBL4950108

O=C(Cl)c1cccc(Cc2cccc(C(=O)Cl)c2)c1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
TSHR P16473 1/20 0.48
PRSS1 P07477 1/20 0.48
PRSS2 P07478 1/20 0.48
PRSS3 P35030 1/20 0.48
FOLH1 Q04609 1/20 0.47
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.42
CYP4F2 P78329 1/20 0.41
CYP4A11 Q02928 1/20 0.41
MRGPRX4 Q96LA9 3/20 0.40
PTPN1 P18031 1/20 0.40
PLA2G10 O15496 1/20 0.39
PLA2G2A P14555 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6201817 0.94 PRSS1 (0.58) ALDH1A1TSHRPRSS1PRSS2PRSS3
SCHEMBL7136015 0.92 PRSS1 (0.47) ALDH1A1TSHRPRSS1PRSS2PRSS3
SCHEMBL39676 0.85 TSHR (0.47) ALDH1A1TSHRFOLH1CA1CA2
SCHEMBL16240333 0.85 PRSS1 (0.55) ALDH1A1TSHRPRSS1PRSS2PRSS3
SCHEMBL29472003 0.85 TSHR (0.47) ALDH1A1TSHRFOLH1CA1CA2
SCHEMBL46611 0.83 ALDH1A1 (0.46) ALDH1A1TSHRFOLH1LOXL2CYP4F2
SCHEMBL9929337 0.83 ALDH1A1 (0.46) ALDH1A1TSHRFOLH1LOXL2CYP4F2
SCHEMBL40196 0.83 ALDH1A1 (0.46) ALDH1A1TSHRFOLH1LOXL2CYP4F2
SCHEMBL18412078 0.83 ALDH1A1 (0.46) ALDH1A1TSHRFOLH1LOXL2CYP4F2
SCHEMBL27999087 0.83 ALDH1A1 (0.46) ALDH1A1TSHRFOLH1LOXL2CYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4910233-A Using aromatic polymer having methylene connecting groups THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1990-03-20 US claimed
US-4661558-A DIELS-ALDER REACTION USING BIS-UNSATURATED DIENOPHILES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS & SPACE ADMINISTRATION (US) 1987-04-28 US claimed
EP-3762447-A1 METHOD FOR PRODUCING FIBRES, FILMS AND MOULDED BODIES OF A POLYBENZAZOLE POLYMER (P) BASF SE (DE) 2021-01-13 EP disclosed
WO-2019170529-A1 METHOD FOR PRODUCING FIBRES, FILMS AND MOULDED BODIES OF A POLYBENZAZOLE POLYMER (P) BASF SE (DE) 2019-09-12 WO disclosed
EP-3512905-A1 METHOD FOR PRODUCING A POLYBENZAZOL POLYMER (P) BASF SE (DE) 2019-07-24 EP disclosed
US-20080146768-A1 PROCESSES FOR PREPARING POLYMERS USING ALPHA,OMEGA-DIFUNCTIONAL ALDARAMIDES E. I. DU PONT DE NEMOURS AND COMPANY 2008-06-19 US disclosed
EP-1858955-A1 PROCESSES USING ALPHA, OMEGA-DIFUNCTIONAL ALDARAMIDES AS MONOMERS AND CROSSLINKERS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2007-11-28 EP disclosed
US-20060264672-A1 Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers E. I. DU PONT DE NEMOURS AND COMPANY 2006-11-23 US disclosed
WO-2006091901-A1 PROCESSES USING ALPHA, OMEGA-DIFUNCTIONAL ALDARAMIDES AS MONOMERS AND CROSSLINKERS E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-08-31 WO disclosed
US-5670493-A ANGIOGENESIS INHIBITORS ADIR ET COMPAGNIE (FR) 1997-09-23 US disclosed
US-4910233-A Using aromatic polymer having methylene connecting groups THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1990-03-20 US disclosed
US-4803151-A Photographic material for the silver dye bleach process comprising an AZO dye, capable of laking, in gelatine CIBA-GEIGY AG (CH) 1989-02-07 US disclosed
US-4661558-A DIELS-ALDER REACTION USING BIS-UNSATURATED DIENOPHILES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS & SPACE ADMINISTRATION (US) 1987-04-28 US disclosed
US-4118232-A Photographic material containing sulphonic acid group containing disazo dyestuffs CIBA-GEIGY AG (CH) 1978-10-03 US disclosed
US-4051123-A Sulfonic-acid-group containing disazo dyestuffs CIBA-GEIGY AG (CH) 1977-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060264672-A1 Processes using alpha, omega-difunctional aldaramides as monomers and crosslinkers ALOX5, GSTO1, FASN ALDH1A1 40/4885TSHR 4512/4885PRSS1 3666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.