Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL10455580 | 0.96 | MEN1 (0.83) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL11155260 | 0.92 | MEN1 (0.77) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL112367 | 0.92 | — | — | |
| Tromethamine SCHEMBL3995787 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL1417748 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL975 | 0.88 | — | — | |
| Tromethamine SCHEMBL17484 | 0.88 | MEN1 (1.00) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL3696191 | 0.88 | — | — | |
| Tromethamine SCHEMBL6427079 | 0.84 | — | — | |
| Tromethamine SCHEMBL445853 | 0.84 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4033908-A | Polyisocyanurate compositions and foams of improved friability and process of preparing same | GENERAL LATEX AND CHEMICAL CORPORATION (US) | 1977-07-05 | — | — | US | claimed |
| US-10470465-B2 | Glomus iranicum var. tenuihypharum var. nov. strain and use thereof as biostimulant | SYMBORG, S.L. (ES) | 2019-11-12 | — | — | US | disclosed |
| US-10281429-B2 | Semiconductor micro-analysis chip and method of manufacturing the same | KABUSHIKI KAISHA TOSHIBA (JP) | 2019-05-07 | — | — | US | disclosed |
| US-10279348-B2 | Semiconductor micro-analysis chip and method of manufacturing the same | KABUSHIKI KAISHA TOSHIBA (JP) | 2019-05-07 | — | — | US | disclosed |
| US-10113947-B2 | Semiconductor analysis chip and particle inspection method | KABUSHIKI KAISHA TOSHIBA (JP) | 2018-10-30 | — | — | US | disclosed |
| US-20180168167-A1 | GLOMUS IRANICUM VAR. TENUIHYPHARUM VAR. NOV. STRAIN AND USE THEREOF AS BIOSTIMULANT | CORTEVA AGRISCIENCE LLC | 2018-06-21 | — | — | US | disclosed |
| CN-105452844-B | Semiconductor microanalysis chip and method for manufacturing the same | 株式会社东芝 | 2018-05-22 | — | — | CN | disclosed |
| US-9932647-B2 | Glomus iranicum var. tenuihypharum var. nov. strain and use thereof as bio-nematicide | SYMBORG, S.L. (ES) | 2018-04-03 | — | — | US | disclosed |
| US-9895691-B2 | Analysis package for detecting particles in a sample liquid | KABUSHIKI KAISHA TOSHIBA (JP) | 2018-02-20 | — | — | US | disclosed |
| US-9804116-B2 | Method and device for detecting sample | KABUSHIKI KAISHA TOSHIBA (JP) | 2017-10-31 | — | — | US | disclosed |
| WO-2015022834-A1 | SEMICONDUCTOR MICRO-ANALYSIS CHIP AND METHOD OF MANUFACTURING THE SAME | KABUSHIKI KAISHA TOSHIBA (JP) | 2015-02-19 | — | — | WO | disclosed |
| US-20150041316-A1 | SEMICONDUCTOR MICRO-ANALYSIS CHIP AND METHOD OF MANUFACTURING THE SAME | KABUSHIKI KAISHA TOSHIBA (JP) | 2015-02-12 | — | — | US | disclosed |
| WO-2015000612-A1 | GLOMUS IRANICUM VAR. TENUIHYPHARUM VAR. NOV. STRAIN AND USE THEREOF AS BIO-STIMULANT | SYMBORG, S.L. (ES) | 2015-01-08 | — | — | WO | disclosed |
| WO-2015000613-A1 | GLOMUS IRANICUM VAR. TENUIHYPHARUM VAR. NOV. STRAIN AND USE THEREOF AS BIO-NEMATICIDE | SYMBORG, S.L. (ES) | 2015-01-08 | — | — | WO | disclosed |
| EP-2821478-A1 | Glomus iranicum var. tenuihypharum var. nov. strain and its use as bio-nematicide | Symborg, S.L. (ES) | 2015-01-07 | — | — | EP | disclosed |
| EP-2820953-A1 | Glomus iranicum var. tenuihypharum var. nov. strain and its use as biostimulant | Symborg, S.L. (ES) | 2015-01-07 | — | — | EP | disclosed |
| WO-2008090517-A2 | ENRICHED PLANT EXTRACT, COMPOUND, AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2008-07-31 | — | — | WO | disclosed |
| US-20020102601-A1 | Mastitis assay | FITZPATRICK JULIE LYDIA (GB) | 2002-08-01 | — | — | US | disclosed |
| EP-1025440-A1 | MASTITIS ASSAY | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999021003-A1 | MASTITIS ASSAY | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 1999-04-29 | — | — | WO | disclosed |