Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 2/20 | 0.49 |
| ▸ | NQO2 | P16083 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11194565 | 0.74 | KDM4E (0.61) | KDM4EALDH1A1HPGDNQO2MEN1 | |
| SCHEMBL17423119 | 0.74 | POLB (0.55) | KDM4EALDH1A1KMT2APOLBNR4A2 | |
| SCHEMBL23612613 | 0.74 | NQO2 (0.74) | KDM4EALDH1A1NQO2MEN1KMT2A | |
| SCHEMBL9178411 | 0.74 | NQO2 (0.74) | KDM4EALDH1A1NQO2MEN1KMT2A | |
| SCHEMBL9709249 | 0.73 | MAOA (0.72) | KDM4EALDH1A1HPGDNQO2POLB | |
| SCHEMBL19460550 | 0.73 | PPARG (0.46) | KDM4EALDH1A1HPGDELANEMEN1 | |
| SCHEMBL901670 | 0.72 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDNQO2MEN1 | |
| SCHEMBL20535915 | 0.72 | KDM4E (0.62) | KDM4EALDH1A1NQO2MEN1KMT2A | |
| SCHEMBL17792040 | 0.72 | ACHE (0.49) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL13729067 | 0.72 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDELANENQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220306603-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2022-09-29 | — | — | US | disclosed |
| WO-2020248075-A9 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2021-10-21 | — | — | WO | disclosed |
| WO-2020248075-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) | 2020-12-17 | — | — | WO | disclosed |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | KOSAK KENNETH M | 2008-02-28 | — | — | US | disclosed |
| WO-2007040469-A2 | CHLOROQUINE COUPLED COMPOSITIONS AND METHODS FOR THEIR SYNTHESIS | KOSAK KEN M (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | KOSAK KENNETH M | 2007-03-15 | — | — | US | disclosed |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | KOSAK KENNETH M | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060499-A1 | Chloroquine combination drugs and methods for their synthesis | CHMP4B, CTSA, CLTA | KDM4E 2153/4885ALDH1A1 4767/4885HPGD 4728/4885 |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | CHMP4B, CTSA, CLTA | KDM4E 2091/4885ALDH1A1 4743/4885HPGD 4725/4885 |
| US-20220306603-A1 | TARGETING DNA REPAIR IN TUMOR CELLS VIA INHIBITION OF ERCC1-XPF | ERCC4, ERCC1, ERCC2 | KDM4E 3255/4885ALDH1A1 3371/4885HPGD 1656/4885 |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | TLR9, TLR3, EXOSC5 | KDM4E 3418/4885ALDH1A1 4696/4885HPGD 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.