Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959574 | 0.89 | LMNA (0.57) | LMNATSHRSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL4959569 | 0.83 | ALDH1A1 (0.54) | LMNAALDH1A1PKMMAPK1HSD11B1 | |
| SCHEMBL4955012 | 0.78 | DRD2 (0.50) | SMN1; SMN2ALDH1A1PKMHSD11B1MAPT | |
| SCHEMBL2157251 | 0.77 | TSHR (0.71) | LMNATSHRSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL2155086 | 0.77 | LMNA (0.58) | LMNATSHRSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL5501832 | 0.76 | LMNA (0.69) | LMNATSHRSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL2156464 | 0.76 | LMNA (0.53) | LMNATSHRSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL28599511 | 0.74 | HTR3E (0.73) | LMNATSHRSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL29656856 | 0.74 | HTR3E (0.73) | LMNATSHRSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL12395361 | 0.74 | LMNA (0.54) | LMNATSHRSMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194520-A1 | Sulfonyl Amino Cyclic Derivatives and Use Thereof | MERCK SERONO SA (CH) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194520-A1 | Sulfonyl Amino Cyclic Derivatives and Use Thereof | GLS2, SRM, GLS | LMNA 3423/4885TSHR 1187/4885SMN1; SMN2 1149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.