Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSC | P53634 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23663150 | 0.90 | L3MBTL1 (0.57) | L3MBTL1SMN1; SMN2KMT2ATP53CASP1 | |
| SCHEMBL23663155 | 0.86 | SMN1; SMN2 (0.56) | L3MBTL1SMN1; SMN2KMT2ATP53CASP1 | |
| SCHEMBL4961548 | 0.85 | L3MBTL1 (0.52) | L3MBTL1SMN1; SMN2KMT2ATP53CASP1 | |
| SCHEMBL7208159 | 0.84 | THRB (0.57) | L3MBTL1ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL4964380 | 0.84 | THRB (0.57) | L3MBTL1ALDH1A1BRD4BRD2BRD3 | |
| SCHEMBL6273662 | 0.81 | SMN1; SMN2 (0.51) | L3MBTL1SMN1; SMN2KMT2ATP53CASP1 | |
| SCHEMBL23663175 | 0.81 | CTSL (0.48) | L3MBTL1SMN1; SMN2KMT2ATP53CASP1 | |
| SCHEMBL6269972 | 0.80 | THRB (0.62) | L3MBTL1SMN1; SMN2TP53ALDH1A1MCOLN3 | |
| SCHEMBL7044445 | 0.80 | L3MBTL1 (0.51) | L3MBTL1SMN1; SMN2KMT2ATP53CASP1 | |
| SCHEMBL7040382 | 0.80 | THRB (0.53) | L3MBTL1SMN1; SMN2KMT2AALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146686-B1 | Hair conditioning composition comprising polyalkylsiloxane mixture, aminosilicone and silicone copolymer emulsion | PROCTER & GAMBLE (US) | 2013-07-24 | — | — | EP | disclosed |
| US-20080292574-A1 | HAIR CONDITIONING COMPOSITION COMPRISING POLYALKYLSILOXANE MIXTURE, AMINOSILICONE, AND SILICONE COPOLYMER EMULSION | THE PROCTER & GAMBLE COMPANY | 2008-11-27 | — | — | US | disclosed |
| EP-1268404-B1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | PFIZER PROD INC (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20070173548-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | CHIANG YUAN-CHING P | 2007-07-26 | — | — | US | disclosed |
| US-7202275-B2 | Malonamic acids and derivatives thereof as thyroid receptor ligands | WARNER LAMBERT COMPANY LLC (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050209333-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | CHIANG YUAN-CHING P | 2005-09-22 | — | — | US | disclosed |
| US-6924310-B2 | Malonamic acids and derivatives thereof as thyroid receptor ligands | PFIZER INC. (US) | 2005-08-02 | — | — | US | disclosed |
| US-20040077694-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | CHIANG YUAN-CHING P (US) | 2004-04-22 | — | — | US | disclosed |
| US-6664291-B2 | Aromatic amidealkyl acid or ester or amide or hydroxy derivatives are useful in the treatment of obesity, overweight condition, hyperlipidemia, glucoma, cardiac arrhythmias, thyroid disease, skin disoders and diabetes | PFIZER, INC. | 2003-12-16 | — | — | US | disclosed |
| EP-1268404-A1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20010051657-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | PFIZER INC. | 2001-12-13 | — | — | US | disclosed |
| WO-2001072692-A1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080292574-A1 | HAIR CONDITIONING COMPOSITION COMPRISING POLYALKYLSILOXANE MIXTURE, AMINOSILICONE, AND SILICONE COPOLYMER EMULSION | ITCH, CUTA, SMURF1 | L3MBTL1 4045/4885SMN1; SMN2 3393/4885KMT2A 323/4885 |
| US-20070173548-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | THRA, MC1R, TSHR | L3MBTL1 1440/4885SMN1; SMN2 4870/4885KMT2A 3859/4885 |
| US-20050209333-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | THRA, MC1R, TSHR | L3MBTL1 1440/4885SMN1; SMN2 4870/4885KMT2A 3859/4885 |
| US-20040077694-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | THRA, MC1R, TSHR | L3MBTL1 1368/4885SMN1; SMN2 4866/4885KMT2A 3893/4885 |
| US-20010051657-A1 | Malonamic acids and derivatives thereof as thyroid receptor ligands | THRA, MC1R, THRB | L3MBTL1 1241/4885SMN1; SMN2 4865/4885KMT2A 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.