Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951482 | 0.92 | ALDH1A1 (0.52) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL11884778 | 0.80 | MAPT (0.37) | TDP1ALDH1A1HSD17B10CYP3A4ALOX15 | |
| SCHEMBL6822568 | 0.77 | TDP1 (0.44) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL5498504 | 0.75 | ALDH1A3 (0.37) | ALDH1A1HSD17B10 | |
| SCHEMBL8516545 | 0.73 | TDP1 (0.44) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL2786299 | 0.73 | TDP1 (0.44) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL4892692 | 0.73 | TDP1 (0.44) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL3337536 | 0.73 | TDP1 (0.44) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL2350755 | 0.73 | TDP1 (0.56) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL27337982 | 0.73 | TDP1 (0.56) | TDP1ALDH1A1TSHRHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727269-B1 | ACROMEGALY, PITUITARY ADENOMA OR ENDOCRINE GASTROENTEROPANCEATIC TUMORS INCLUDING THE CARCINOID SYNDROME, AND GASTROINTESTINAL BLEEDING | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-27 | — | — | US | claimed |
| US-7470815-B1 | Selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2008-12-30 | — | — | US | disclosed |
| US-7220765-B2 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (SCRAS) (FR) | 2007-05-22 | — | — | US | disclosed |
| US-20070043095-A1 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | IPSEN PHARMA S.A.S. (FR) | 2007-02-22 | — | — | US | disclosed |
| US-20050159363-A1 | Selective neuronal nitric oxide synthase inhibitors | SILVERMAN RICHARD B (US) | 2005-07-21 | — | — | US | disclosed |
| US-6803486-B2 | PEPTIDOMIMETIC; N-AMINOBUTYL-N'-NITROGUANIDINE DERIVATIVES | NORTHWESTERN UNIVERSITY | 2004-10-12 | — | — | US | disclosed |
| US-6727269-B1 | ACROMEGALY, PITUITARY ADENOMA OR ENDOCRINE GASTROENTEROPANCEATIC TUMORS INCLUDING THE CARCINOID SYNDROME, AND GASTROINTESTINAL BLEEDING | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-04-27 | — | — | US | disclosed |
| US-20030119751-A1 | Selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY | 2003-06-26 | — | — | US | disclosed |
| WO-2003000198-A2 | SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS | NORTHWESTERN UNIVERSITY (US) | 2003-01-03 | — | — | WO | disclosed |
| US-4217272-A | DYEING CELLULOSIC FIBERS | STERLING DRUG INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4153598-A | Monoazo and diazo colorants from aminoalkylanilines and bis(aminoalkyl)anilines | STERLING DRUG INC. (US) | 1979-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159363-A1 | Selective neuronal nitric oxide synthase inhibitors | NOS1, NOS3, NOS2 | TDP1 1350/4885ALDH1A1 1959/4885TSHR 3793/4885 |
| US-20070043095-A1 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | SSTR2, SSTR5, SSTR3 | TDP1 4518/4885ALDH1A1 812/4885TSHR 33/4885 |
| US-20030119751-A1 | Selective neuronal nitric oxide synthase inhibitors | NOS1, NOS3, NOS2 | TDP1 1350/4885ALDH1A1 1959/4885TSHR 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.