Sugi Predict

Sugi Predict / Compounds / SCHEMBL496967

SCHEMBL496967

SCHEMBL496967

O=C(O)Cc1ccc2nc[nH]c(=O)c2c1

nearest known ligand 0.65

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ IP6K1 Q92551 7/20 0.65
▸ IP6K3 Q96PC2 3/20 0.65
▸ IP6K2 Q9UHH9 3/20 0.65
▸ PARP1 P09874 7/20 0.58
▸ SLC2A1 P11166 1/20 0.56
▸ CHEK1 O14757 1/20 0.54
▸ PIM1 P11309 1/20 0.54
▸ AKT1 P31749 1/20 0.54
▸ FLT3 P36888 1/20 0.54
▸ PIM3 Q86V86 1/20 0.54
▸ DHFR P00374 3/20 0.49
▸ KDM4E B2RXH2 1/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ MAPT P10636 1/20 0.49
▸ HPGD P15428 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ HSD17B10 Q99714 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22980875 0.83 IP6K1 (0.66) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL7427860 0.81 IP6K1 (0.68) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL2698529 0.80 SLC2A1 (0.54) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL9911097 0.80 IP6K1 (0.66) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL5151137 0.80 NAMPT (0.55) KDM4EMEN1ALDH1A1MAPTHPGD
SCHEMBL256397 0.78 ROCK2 (0.50) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL27947190 0.77 IP6K1 (0.62) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL8170598 0.77 IP6K1 (0.71) IP6K1IP6K3IP6K2PARP1SLC2A1
SCHEMBL980102 0.76 KDM4E (0.53) KDM4EMEN1ALDH1A1MAPTHPGD
SCHEMBL263154 0.76 SLC2A1 (0.74) IP6K1IP6K3IP6K2PARP1SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570615-B2 Quinazolinone derivatives HOFFMANN-LA ROCHE INC. 2026-03-10 — — US disclosed
US-20230331682-A1 NEW QUINAZOLINONE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2023-10-19 — — US disclosed
EP-3093289-A1 [1,2,4]TRIAZOLO[4,3-A]PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR Amgen, Inc (US) 2016-11-16 — — EP disclosed
EP-2081931-B1 [1,2,4]Triazolo[4,3-a]pyridine derivatives useful as inhibitors of the hepatocyte growth factor receptor AMGEN INC (US) 2016-08-31 — — EP disclosed
US-9066954-B2 Fused heterocyclic derivatives and methods of use AMGEN INC. (US) 2015-06-30 — — US disclosed
US-20130303529-A1 FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE AMGEN INC (US) 2013-11-14 — — US disclosed
US-8524900-B2 Fused heterocyclic derivatives and methods of use AMGEN INC. (US) 2013-09-03 — — US disclosed
EP-2578583-A1 Fused heterocyclic derivatives and methods of use Amgen Inc. (US) 2013-04-10 — — EP disclosed
CN-101528743-B Fused heterocyclic derivatives and methods of use AMGEN INC 2013-02-06 — — CN disclosed
US-8217177-B2 Fused heterocyclic derivatives and methods of use AMGEN INC. (US) 2012-07-10 — — US disclosed
WO-2008008539-A2 FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR AMGEN INC. (US) 2008-01-17 — — WO disclosed
US-20070021447-A1 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) 2007-01-25 — — US disclosed
US-20060122176-A1 Azolidinone-vinyl fused-benzene derivatives MERCK SERONO SA (CH) 2006-06-08 — — US disclosed
EP-1648452-A1 2-IMINO-4-(THIO)OXO-5-POLYCYCLOVINYLAZOLINES FOR USE AS PI3 KINASE INHIBITORS Applied Research Systems ARS Holding N.V. (AN) 2006-04-26 — — EP disclosed
US-20050222225-A1 Use of compounds for increasing spermatozoa motility APPLIED RESEARCH SYSTEMS ARS HOLDING NV (NL) 2005-10-06 — — US disclosed
EP-1549644-A1 AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES Applied Research Systems ARS Holding N.V. (AN) 2005-07-06 — — EP disclosed
EP-1531813-A1 USE OF COMPOUNDS FOR INCREASING SPERMATOZOA MOTILITY Applied Research Systems ARS Holding N.V. (AN) 2005-05-25 — — EP disclosed
WO-2005011686-A1 2-IMINO-4-(THIO) OXO-5-POLY CYCLOVINYLAZOLINES FOR USE AS P13 KINASE IHIBITORS APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) 2005-02-10 — — WO disclosed
WO-2004007491-A1 AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2004-01-22 — — WO disclosed
WO-2004006916-A1 USE OF COMPOUNDS FOR INCREASING SPERMATOZOA MOTILITY APPLIED RESEARCH SYSTEMS ARS HOLDING NV (AN) 2004-01-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230331682-A1 NEW QUINAZOLINONE DERIVATIVES NDUFS3, NQO2, NDUFC1 IP6K1 3059/4885IP6K3 2763/4885IP6K2 3316/4885
US-20070021447-A1 2-Imino-4-(thio)oxo-5-poly cyclovinylazolines for use as p13 kinase ihibitors PI4K2B, PI4KA, PTK2B IP6K1 9/4885IP6K3 6/4885IP6K2 8/4885
US-20050222225-A1 Use of compounds for increasing spermatozoa motility CATSPER1, PI4KB, MAN2B2 IP6K1 45/4885IP6K3 23/4885IP6K2 66/4885
US-20130303529-A1 FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE HGF, HGFAC, MET IP6K1 3165/4885IP6K3 3105/4885IP6K2 3446/4885
US-20060122176-A1 Azolidinone-vinyl fused-benzene derivatives BRCA1, ZAP70, F13B IP6K1 2625/4885IP6K3 2662/4885IP6K2 2627/4885
US-12570615-B2 Quinazolinone derivatives ABL1, NQO2, CNR1 IP6K1 3577/4885IP6K3 3189/4885IP6K2 3801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.