Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.43 |
| ▸ | POLQ | O75417 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979253 | 0.84 | CYP11B2 (0.46) | CYP11B1CYP11B2KCNA5KCNH2 | |
| SCHEMBL4975773 | 0.82 | KCNA5 (0.39) | CYP11B1CYP11B2KCNA5KCNH2CYP3A4 | |
| SCHEMBL4980305 | 0.82 | KCNA5 (0.39) | CYP11B1CYP11B2GPBAR1KCNA5KCNH2 | |
| SCHEMBL4979558 | 0.79 | CYP11B2 (0.48) | CYP11B1CYP11B2CYP19A1KCNA5KCNH2 | |
| SCHEMBL4982009 | 0.77 | MKNK1 (0.47) | CYP11B1CYP11B2KCNA5KCNH2 | |
| SCHEMBL4974371 | 0.76 | KCNA5 (0.50) | CYP11B1CYP11B2KCNA5KCNH2CYP3A4 | |
| SCHEMBL4977077 | 0.76 | CYP11B1 (0.53) | CYP11B1CYP11B2 | |
| SCHEMBL4977669 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2KCNA5KCNH2CYP3A4 | |
| SCHEMBL4975675 | 0.75 | MKNK1 (0.47) | CYP11B1CYP11B2KCNA5 | |
| SCHEMBL4975470 | 0.75 | KCNA5 (0.51) | CYP11B1CYP11B2KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |