Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | PTAFR | P25105 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977669 | 0.87 | CYP11B1 (0.54) | PTAFRCYP11B1CYP11B2KCNA5HTT | |
| SCHEMBL4975675 | 0.86 | MKNK1 (0.47) | MKNK1MKNK2PTAFRCYP11B1CYP11B2 | |
| SCHEMBL4975764 | 0.83 | CYP46A1 (0.53) | PTAFR | |
| SCHEMBL4977077 | 0.81 | CYP11B1 (0.53) | PTAFRCYP11B1CYP11B2HTTGAA | |
| SCHEMBL4979253 | 0.80 | CYP11B2 (0.46) | CYP11B1CYP11B2KCNA5KCNH2 | |
| SCHEMBL4975773 | 0.80 | KCNA5 (0.39) | CYP11B1CYP11B2KCNA5TSHRKCNH2 | |
| SCHEMBL4980305 | 0.80 | KCNA5 (0.39) | CYP11B1CYP11B2KCNA5HTTKCNH2 | |
| SCHEMBL2984193 | 0.79 | MKNK1 (0.53) | MKNK1MKNK2CHEK2PTAFRF7 | |
| SCHEMBL4977530 | 0.77 | CYP11B1 (0.48) | CYP11B1CYP11B2KCNA5KCNH2 | |
| SCHEMBL4979558 | 0.77 | CYP11B2 (0.48) | CYP11B1CYP11B2KCNA5GAAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |