Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4979253 | 0.82 | CYP11B2 (0.46) | CYP11B2CYP11B1KCNA5KCNH2 | |
| SCHEMBL4975773 | 0.82 | KCNA5 (0.39) | CYP11B2CYP11B1CYP17A1KCNA5KCNH2 | |
| SCHEMBL4980305 | 0.82 | KCNA5 (0.39) | CYP11B2CYP11B1KCNA5KCNH2MAPK1 | |
| SCHEMBL4977530 | 0.79 | CYP11B1 (0.48) | CYP11B2CYP11B1CYP19A1KCNA5KCNH2 | |
| SCHEMBL4982009 | 0.77 | MKNK1 (0.47) | CYP11B2CYP11B1KCNA5KCNH2GAA | |
| SCHEMBL4974371 | 0.76 | KCNA5 (0.50) | CYP11B2CYP11B1KCNA5KCNH2ADRA2C | |
| SCHEMBL4977077 | 0.76 | CYP11B1 (0.53) | CYP11B2CYP11B1KDM4EGAA | |
| SCHEMBL4977669 | 0.76 | CYP11B1 (0.54) | CYP11B2CYP11B1KCNA5KCNH2GLA | |
| SCHEMBL4975675 | 0.75 | MKNK1 (0.47) | CYP11B2CYP11B1KCNA5GAA | |
| SCHEMBL4975470 | 0.75 | KCNA5 (0.51) | CYP11B2CYP11B1KCNA5KCNH2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |