Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982009 | 0.87 | MKNK1 (0.47) | CYP11B1CYP11B2KCNA5KCNH2HTT | |
| SCHEMBL4975675 | 0.86 | MKNK1 (0.47) | CYP11B1CYP11B2KCNA5TRPV1PTAFR | |
| SCHEMBL4975764 | 0.81 | CYP46A1 (0.53) | ALDH1A1PTAFRMEN1KMT2AROCK2 | |
| SCHEMBL4977077 | 0.81 | CYP11B1 (0.53) | CYP11B1CYP11B2HTTHSD17B10ALDH1A1 | |
| SCHEMBL4975773 | 0.81 | KCNA5 (0.39) | CYP11B1CYP11B2KCNA5KCNH2CYP1A2 | |
| SCHEMBL4980305 | 0.78 | KCNA5 (0.39) | CYP11B1CYP11B2KCNA5KCNH2HTT | |
| SCHEMBL4979253 | 0.78 | CYP11B2 (0.46) | CYP11B1CYP11B2KCNA5KCNH2 | |
| SCHEMBL4981246 | 0.77 | KMT2A (0.48) | CYP11B1CYP11B2KCNA5KCNH2HTT | |
| SCHEMBL4977530 | 0.76 | CYP11B1 (0.48) | CYP11B1CYP11B2KCNA5KCNH2CYP3A4 | |
| SCHEMBL4979558 | 0.76 | CYP11B2 (0.48) | CYP11B1CYP11B2KCNA5KCNH2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993551-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007089735-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | claimed |