Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.51 |
| ▸ | AKT1 | P31749 | 4/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.51 |
| ▸ | GSK3A | P49840 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045241 | 0.95 | ALDH1A1 (0.55) | ALDH1A1LMNAJAK2TYK2GSK3B | |
| SCHEMBL4978745 | 0.92 | SLC6A9 (0.56) | ALDH1A1LMNAJAK2TYK2GSK3B | |
| SCHEMBL14595547 | 0.88 | LMNA (0.56) | ALDH1A1LMNACYP3A4KMT2AHTT | |
| SCHEMBL7047478 | 0.86 | SLC6A9 (0.56) | ALDH1A1GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL7048161 | 0.82 | ALDH1A1 (0.55) | ALDH1A1GSK3BROCK1CLK4RPS6KA5 | |
| SCHEMBL6707539 | 0.79 | ALDH1A1 (0.48) | ALDH1A1LMNAGSK3BROCK1CLK4 | |
| SCHEMBL14595548 | 0.79 | NPC1 (0.63) | ALDH1A1LMNAMEN1KMT2AKCNK3 | |
| SCHEMBL17663830 | 0.76 | S1PR3 (0.73) | — | |
| SCHEMBL28457962 | 0.75 | TDP1 (0.55) | ALDH1A1LMNACYP3A4EPHX2HPGD | |
| SCHEMBL1649573 | 0.75 | CA1 (0.69) | ALDH1A1LMNACYP3A4HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426503-A | Compositions and methods of treatment for inhibiting kinase and/or HMG-COA reductase | PHARMIX CORP (US) | 2009-05-06 | — | — | CN | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2008-01-24 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199126-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| EP-1755607-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | Pharmix Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| US-7183285-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183285-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-02-27 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20060084695-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2006-04-20 | — | — | US | disclosed |
| WO-2006028524-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | PHARMIX CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
| US-20050288306-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-29 | — | — | US | disclosed |
| US-20050282883-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-22 | — | — | US | disclosed |
| US-20050277653-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-15 | — | — | US | disclosed |
| US-20050272770-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-12-08 | — | — | US | disclosed |
| US-20050261354-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | NUMERATE, INC. | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288306-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
| US-20050282883-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | ALDH1A1 1725/4885LMNA 1101/4885JAK2 1865/4885 |
| US-20060084695-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
| US-20050277653-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
| US-20050261354-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
| US-20080021054-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
| US-20050272770-A1 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | HMGCR, HMGB3, HMGB2 | ALDH1A1 1658/4885LMNA 1079/4885JAK2 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.