Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PKLR | P30613 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4987016 | 0.97 | PKM (0.51) | PKMNPC1PKLRRAB9AMKNK1 | |
| SCHEMBL4980965 | 0.91 | SMN1; SMN2 (0.49) | MKNK1HTTALDH1A1LMNATSHR | |
| SCHEMBL4985250 | 0.89 | LMNA (0.40) | PKMMKNK1HTTALDH1A1LMNA | |
| SCHEMBL4982880 | 0.86 | L3MBTL1 (0.42) | MKNK1HTTHSD11B1ALDH1A1L3MBTL1 | |
| SCHEMBL4980438 | 0.85 | MMP1 (0.40) | MKNK1HTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4989425 | 0.85 | MMP2 (0.40) | MKNK1HTTALDH1A1KDM4ELMNA | |
| SCHEMBL4988177 | 0.85 | MKNK1 (0.47) | PKMPKLRMKNK1ALDH1A1LMNA | |
| SCHEMBL4988330 | 0.84 | CD4 (0.50) | PKMRAB9AHTTHSD11B1ALDH1A1 | |
| SCHEMBL4992079 | 0.83 | CYP3A4 (0.58) | PKMHTTHSD11B1ALDH1A1KDM4E | |
| SCHEMBL4982847 | 0.83 | LMNA (0.41) | PKMMKNK1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | PKM 1098/4885NPC1 2233/4885PKLR 1213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.