Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650646 | 0.81 | PPARG (0.61) | PPARGPPARAPPARDRAB9AMAPT | |
| SCHEMBL6200075 | 0.78 | PPARG (0.51) | PPARGPPARAPPARDRAB9AMAPT | |
| SCHEMBL28727724 | 0.75 | PPARG (0.49) | PPARGPPARAPPARDRAB9AMAPT | |
| SCHEMBL1833135 | 0.69 | LTA4H (0.54) | PPARGPPARAPPARDRAB9AMAPT | |
| SCHEMBL1833133 | 0.69 | LTA4H (0.54) | PPARGPPARAPPARDRAB9AMAPT | |
| SCHEMBL28082367 | 0.69 | PPARA (0.63) | PPARGPPARAPPARDTDP1 | |
| SCHEMBL24351834 | 0.69 | S1PR1 (0.39) | PPARGPPARAMAPTCYP1A2SMN1; SMN2 | |
| Formic Acid SCHEMBL27596947 | 0.68 | LMNA (0.55) | PPARGPPARARAB9AMTNR1AMTNR1B | |
| SCHEMBL1805351 | 0.68 | TDP1 (0.57) | PPARGPPARARAB9AMAPTMTNR1A | |
| SCHEMBL12141802 | 0.68 | MTNR1A (0.47) | PPARGPPARAPPARDRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396940-B2 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid | HOFFMANN-LA ROCHE INC. (US) | 2008-07-08 | — | — | US | disclosed |
| WO-2005040111-A2 | COMBINATORIAL LIBRARY OF 3-ARYL-1H-INDOLE-2-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (DE) | 2005-05-06 | — | — | WO | disclosed |
| WO-2005040073-A2 | SOLID PHASE SYNTHESIS OF 3-ARYL-2- INDOLYLCARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |
| US-20050089935-A1 | Combinatorial library of 3-aryl-1h-indole-2-carboxylic acid | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089935-A1 | Combinatorial library of 3-aryl-1h-indole-2-carboxylic acid | AADAC, KYNU, DDC | PPARG 542/4885PPARA 201/4885PPARD 543/4885 |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | AADAC, KYNU, AANAT | PPARG 692/4885PPARA 236/4885PPARD 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.