Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Mephobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB3 known ✓ | P28472 | 4/20 | 0.44 |
| ▸ | GABRA1 known ✓ | P14867 | 3/20 | 0.44 |
| ▸ | GABRG2 known ✓ | P18507 | 3/20 | 0.44 |
| ▸ | GABRB2 known ✓ | P47870 | 3/20 | 0.44 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MMP9 | P14780 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methohexital SCHEMBL1003787 | 0.82 | LMNA (0.59) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| Mephobarbital SCHEMBL4266723 | 0.81 | LMNA (0.67) | LMNAMMP9GABRB3GABRB2CYP2C19 | |
| Mephobarbital SCHEMBL7777123 | 0.81 | LMNA (0.88) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| (S)-Methylphenobarbital SCHEMBL35625 | 0.78 | LMNA (1.00) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| Mephobarbital SCHEMBL35624 | 0.78 | LMNA (1.00) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| (R)-Methylphenobarbital SCHEMBL11789851 | 0.78 | LMNA (1.00) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| SCHEMBL14788952 | 0.77 | MMP9 (0.50) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| Mephobarbital SCHEMBL29694125 | 0.77 | LMNA (0.97) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| Mephobarbital SCHEMBL28475568 | 0.77 | LMNA (0.97) | LMNAMMP9GABRB3GABRA1GABRG2 | |
| Talbutal SCHEMBL122147 | 0.76 | MMP9 (0.76) | LMNAMMP9GABRB3GABRB2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11925707-B2 | Co-processed lubricant:MCG for tablets | JRS PHARMA GMBH & CO. KG (DE) | 2024-03-12 | — | — | US | disclosed |
| US-20240000798-A1 | MODULATION OF SOLUBILITY, STABILITY, ABSORPTION, METABOLISM, AND PHARMACOKINETIC PROFILE OF LIPOPHILIC DRUGS BY STEROLS | Marius Pharmaceuticals, Inc. | 2024-01-04 | — | — | US | disclosed |
| WO-2023129540-A1 | LUBRICANT FOR PHARMACEUTICALS AND NUTRACEUTICALS | JRS PHARMA GMBH & CO. KG (DE) | 2023-07-06 | — | — | WO | disclosed |
| US-20230201124-A1 | LUBRICANT FOR PHARMACEUTICALS AND NUTRACEUTICALS | JRS PHARMA GMBH & CO. KG (DE) | 2023-06-29 | — | — | US | disclosed |
| US-11617758-B2 | Emulsion formulations | MARIUS PHARMACEUTICALS LLC (US) | 2023-04-04 | — | — | US | disclosed |
| US-11590146-B2 | Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols | MARIUS PHARMACEUTICALS LLC (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210046087-A1 | EMULSION FORMULATIONS | Marius Pharmaceuticals, Inc. | 2021-02-18 | — | — | US | disclosed |
| US-20200390784-A1 | MODULATION OF SOLUBILITY, STABILITY, ABSORPTION, METABOLISM, AND PHARMACOKINETIC PROFILE OF LIPOPHILIC DRUGS BY STEROLS | Marius Pharmaceuticals, Inc. | 2020-12-17 | — | — | US | disclosed |
| US-10576090-B2 | Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols | MARIUS PHARMACEUTICALS LLC (US) | 2020-03-03 | — | — | US | disclosed |
| US-10576089-B2 | Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols | MARIUS PHARMACEUTICALS LLC (US) | 2020-03-03 | — | — | US | disclosed |
| US-20030049208-A1 | Over-coated chewing gum formulations | WM. WRIGLEY JR. COMPANY | 2003-03-13 | — | — | US | disclosed |
| WO-2002087544-A1 | FLAVORED PRODUCT CONTAINING MEDICAMENT OR OTHER ACTIVE AGENT | WM. WRIGLEY JR. COMPANY (US) | 2002-11-07 | — | — | WO | disclosed |
| US-20020164398-A1 | Method and product for accelerating absorption of medicaments through oral mucosa | WM. WRIGLEY JR. COMPANY | 2002-11-07 | — | — | US | disclosed |
| WO-2002071860-A1 | GUM BASE AND GUM MANUFACTURING USING PARTICULATED GUM BASE INGREDIENTS | L.A. DREYFUS CO. (US) | 2002-09-19 | — | — | WO | disclosed |
| WO-2002069729-A1 | GUM BASE AND GUM MANUFACTURING USING PARTICULATED GUM BASE INGREDIENTS | L.A. DREYFUS CO. (US) | 2002-09-12 | — | — | WO | disclosed |
| EP-1221863-A1 | CHEWING GUM CONTAINING MEDICAMENT ACTIVE AGENTS | WM. WRIGLEY JR. COMPANY (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1139774-A4 | IMPROVED RELEASE OF MEDICAMENT ACTIVE AGENTS FROM A CHEWING GUM COATING | WRIGLEY W M JUN CO (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1139774-A1 | IMPROVED RELEASE OF MEDICAMENT ACTIVE AGENTS FROM A CHEWING GUM COATING | WM. WRIGLEY JR. COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035298-A1 | CHEWING GUM CONTAINING MEDICAMENT ACTIVE AGENTS | WM. WRIGLEY JR. COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000035296-A1 | IMPROVED RELEASE OF MEDICAMENT ACTIVE AGENTS FROM A CHEWING GUM COATING | WM. WRIGLEY JR. COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |